4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH

Stable Identifier
R-HSA-390281
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal matrix
Synonyms
(R)-carnitine + 4,8-dimethylnonanoyl-CoA => CoA + O-4,8-dimethylnonanoyl-(R)-carnitine
ReviewStatus
5/5
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4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Peroxisomal CROT catalyzes the reaction of 4,8-dimethylnonanoyl-CoA and carnitine to form 4,8-dimethylnonanoylcarnitine and CoASH (Ferdinandusse et al. 1999).
Literature References
PubMed ID Title Journal Year
10486279 Molecular cloning and expression of human carnitine octanoyltransferase: evidence for its role in the peroxisomal beta-oxidation of branched-chain fatty acids

Ferdinandusse, S, Mulders, J, IJlst, L, Denis, S, Dacremont, G, Waterham, HR, Wanders, RJA

Biochem Biophys Res Commun 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

carnitine O-octanoyltransferase activity of CROT [peroxisomal matrix]

Physical Entity
CROT [peroxisomal matrix] (Homo sapiens)
Activity
carnitine O-octanoyltransferase activity (GO:0008458)
Orthologous Events
4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Bos taurus)
4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Caenorhabditis elegans)
4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Canis familiaris)
4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Danio rerio)
4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Drosophila melanogaster)
4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Gallus gallus)
4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Mus musculus)
4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Rattus norvegicus)
4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Sus scrofa)
4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Xenopus tropicalis)
Cross References
RHEA
Authored
D'Eustachio, P  (2009-03-16)
Reviewed
Jassal, B  (2009-02-27)
Created
D'Eustachio, P  (2009-01-24)
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