phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate

Stable Identifier
R-HSA-389622
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal matrix
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phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

VLCS (very long chain acyl-CoA synthetase), associated with the inner surface of the peroxisomal membrane, cayalyzes the reaction of phytanate, CoA-SH, and ATP to form phytanoyl-CoA, AMP, and pyrophosphate (Steinberg et al. 1999).

Literature References
PubMed ID Title Journal Year
10198260 Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism

Mihalik, SJ, Watkins, PA, Wang, SJ, Kim, DG, Steinberg, SJ

Biochem Biophys Res Commun 1999
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Catalyst Activity

phytanate-CoA ligase activity of SLC27A2 [peroxisomal membrane]

Physical Entity
SLC27A2 [peroxisomal membrane] (Homo sapiens)
Activity
phytanate-CoA ligase activity (GO:0050197)
Orthologous Events
phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Bos taurus)
phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Caenorhabditis elegans)
phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Canis familiaris)
phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Danio rerio)
phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Drosophila melanogaster)
phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Gallus gallus)
phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Mus musculus)
phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Rattus norvegicus)
phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Sus scrofa)
phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2009-01-11)
Reviewed
Jassal, B  (2009-02-27)
Created
D'Eustachio, P  (2009-01-11)
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