phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate

Stable Identifier
R-HSA-389622
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal matrix
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phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

VLCS (very long chain acyl-CoA synthetase), associated with the inner surface of the peroxisomal membrane, cayalyzes the reaction of phytanate, CoA-SH, and ATP to form phytanoyl-CoA, AMP, and pyrophosphate (Steinberg et al. 1999).

Literature References
PubMed ID Title Journal Year
10198260 Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism

Steinberg, SJ, Wang, SJ, Kim, DG, Mihalik, SJ, Watkins, PA

Biochem Biophys Res Commun 1999
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
phytanate-CoA ligase activity of SLC27A2 [peroxisomal membrane]
Physical Entity
SLC27A2 [peroxisomal membrane]
Activity
phytanate-CoA ligase activity (0050197)
Orthologous Events
phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Bos taurus)
phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Caenorhabditis elegans)
phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Canis familiaris)
phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Danio rerio)
phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Drosophila melanogaster)
phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Gallus gallus)
phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Mus musculus)
phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Rattus norvegicus)
phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Saccharomyces cerevisiae)
phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Sus scrofa)
phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2009-01-11)
Reviewed
Jassal, B  (2009-02-27)
Created
D'Eustachio, P  (2009-01-11)
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