Orexin 1 receptor can bind orexin-A neuropeptide

Stable Identifier
R-HSA-389481
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

The orexin (hypocretin) neuropeptides (A and B) both derive from a 131 residue precursor, prepro-orexin peptide (Sakurai T et al, 1999). Orexin A (Takai T et al, 2006) binds preferentially to the orphan GPCR orexin 1 receptor (Sakurai T et al, 1998). This activated complex can transduce its signal via the Gq class of G protein.

Literature References
PubMed ID Title Journal Year
16429482 Orexin-A is composed of a highly conserved C-terminal and a specific, hydrophilic N-terminal region, revealing the structural basis of specific recognition by the orexin-1 receptor

Takai, T, Takaya, T, Nakano, M, Akutsu, H, Nakagawa, A, Aimoto, S, Nagai, K, Ikegami, T

J Pept Sci 2006
10364220 Structure and function of human prepro-orexin gene

Sakurai, T, Moriguchi, T, Furuya, K, Kajiwara, N, Nakamura, T, Yanagisawa, M, Goto, K

J Biol Chem 1999
9491897 Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

Sakurai, T, Amemiya, A, Ishii, M, Matsuzaki, I, Chemelli, RM, Tanaka, H, Williams, SC, Richardson, JA, Kozlowski, GP, Wilson, S, Arch, JR, Buckingham, RE, Haynes, AC, Carr, SA, Annan, RS, McNulty, DE, Liu, WS, Terrett, JA, Elshourbagy, NA, Bergsma, DJ, Yanagisawa, M

Cell 1998
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