Orexin 1 receptor can bind orexin-A neuropeptide

Stable Identifier
R-HSA-389481
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The orexin (hypocretin) neuropeptides (A and B) both derive from a 131 residue precursor, prepro-orexin peptide (Sakurai T et al, 1999). Orexin A (Takai T et al, 2006) binds preferentially to the orphan GPCR orexin 1 receptor (Sakurai T et al, 1998). This activated complex can transduce its signal via the Gq class of G protein.

Participants
Participant Of
Orthologous Events