Orexin 1 receptor can bind orexin-A neuropeptide

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The orexin (hypocretin) neuropeptides (A and B) both derive from a 131 residue precursor, prepro-orexin peptide (Sakurai T et al, 1999). Orexin A (Takai T et al, 2006) binds preferentially to the orphan GPCR orexin 1 receptor (Sakurai T et al, 1998). This activated complex can transduce its signal via the Gq class of G protein.
Literature References
PubMed ID Title Journal Year
10364220 Structure and function of human prepro-orexin gene

Sakurai, T, Yanagisawa, M, Nakamura, T, Moriguchi, T, Goto, K, Kajiwara, N, Furuya, K

J Biol Chem 1999
16429482 Orexin-A is composed of a highly conserved C-terminal and a specific, hydrophilic N-terminal region, revealing the structural basis of specific recognition by the orexin-1 receptor

Nagai, K, Nakagawa, A, Nakano, M, Ikegami, T, Aimoto, S, Akutsu, H, Takaya, T, Takai, T

J Pept Sci 2006
9491897 Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

Chemelli, RM, Terrett, JA, Haynes, AC, Elshourbagy, NA, Sakurai, T, Matsuzaki, I, Amemiya, A, Yanagisawa, M, Buckingham, RE, Kozlowski, GP, Bergsma, DJ, Liu, WS, Carr, SA, Richardson, JA, Ishii, M, Williams, SC, Wilson, S, Annan, RS, McNulty, DE, Tanaka, H, Arch, JR

Cell 1998
Orthologous Events
Cite Us!