Reactome | Gads binds CD28

Gads binds CD28

Stable Identifier

R-HSA-389381

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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GADS (Grb2-related adaptor protein 2) plays a crucial role in CD28-mediated NF-kB activation, which is vital for effective T cell activation and immune responses. This signal is mediated by the direct binding of GADS to the YMNM motif in the cytoplasmic tail of CD28. Additionally, the proline-rich PxxP motif in CD28 is also required for the optimal association of Gads with the CD28 signaling complex. These interactions help bridge CD28 with other intracellular signaling pathways, ensuring robust NF-kB activation and subsequent T cell proliferation and cytokine production (Watanabe et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16818765	Grb2 and Gads exhibit different interactions with CD28 and play distinct roles in CD28-mediated costimulation Watanabe, R, Harada, Y, Takeda, K, Takahashi, J, Ohnuki, K, Ogawa, S, Ohgai, D, Kaibara, N, Koiwai, O, Tanabe, K, Toma, H, Sugamura, K, Abe, R	J Immunol	2006