Reactome | Gads binds CD28

Gads binds CD28

Stable Identifier

R-HSA-389381

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Gads (Grb2-related adaptor protein 2) is essential for CD28 mediated NF-kB activation. This signal is mediated by the binding of Gads to the CD28 YMNM motif. The CD28 cytoplasmic PxxP motif is also required for this association.

Literature References

PubMed ID	Title	Journal	Year
16818765	Grb2 and Gads exhibit different interactions with CD28 and play distinct roles in CD28-mediated costimulation Tanabe, K, Ogawa, S, Takeda, K, Abe, R, Ohgai, D, Takahashi, J, Koiwai, O, Kaibara, N, Sugamura, K, Harada, Y, Toma, H, Watanabe, R, Ohnuki, K	J Immunol	2006