Vav1, once activated by PIP3 binding and phosphorylation by Fyn, stimulates the GDP/GTP exchange activity of Rac. Vav1 is selective for Rac and catalyses exchange of bound GDP for GTP.
Han, J, Luby-Phelps, K, Das, B, Shu, X, Xia, Y, Mosteller, RD, Krishna, UM, Falck, JR, White, MA, Broek, D
Crespo, P, Schuebel, KE, Ostrom, AA, Gutkind, JS, Bustelo, XR
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