Reactome | Activation of Rac1 by pVav1

Activation of Rac1 by pVav1

Stable Identifier

R-HSA-389348

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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Vav1, once activated by PIP3 binding and phosphorylation by Fyn, stimulates the GDP/GTP exchange activity of Rac. Vav1 is selective for Rac and catalyses exchange of bound GDP for GTP.

Literature References

PubMed ID	Title	Journal	Year
9438848	Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav Han, J, Luby-Phelps, K, Das, B, Shu, X, Xia, Y, Mosteller, RD, Krishna, UM, Falck, JR, White, MA, Broek, D	Science	1998
8990121	Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product Crespo, P, Schuebel, KE, Ostrom, AA, Gutkind, JS, Bustelo, XR	Nature	1997