Activation of Rac1 by pVav1

Stable Identifier
R-HSA-389348
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Activation of Rac1 by pVav1
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Vav1, once activated by PIP3 binding and phosphorylation by Fyn, stimulates the GDP/GTP exchange activity of Rac. Vav1 is selective for Rac and catalyses exchange of bound GDP for GTP.

Literature References
PubMed ID Title Journal Year
9438848 Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

Han, J, Luby-Phelps, K, Das, B, Shu, X, Xia, Y, Mosteller, RD, Krishna, UM, Falck, JR, White, MA, Broek, D

Science 1998
8990121 Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

Crespo, P, Schuebel, KE, Ostrom, AA, Gutkind, JS, Bustelo, XR

Nature 1997
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane]
Physical Entity
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane]
Activity
guanyl-nucleotide exchange factor activity (0005085)
Orthologous Events
Activation of Rac1 by pVav1 (Mus musculus)
Activation of Rac1 by pVav1 (Rattus norvegicus)
Activation of Rac1 by pVav1 (Sus scrofa)
Activation of Rac1 by pVav1 (Xenopus tropicalis)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Bluestone, JA  (2009-06-01)
Esensten, J  (2009-06-01)
Created
Garapati, P V  (2009-01-06)