Vav1, once activated by PIP3 binding and phosphorylation by Fyn, stimulates the GDP/GTP exchange activity of Rac. Vav1 is selective for Rac and catalyses exchange of bound GDP for GTP.
Ostrom, AA, Bustelo, XR, Gutkind, JS, Crespo, P, Schuebel, KE
White, MA, Falck, JR, Mosteller, RD, Xia, Y, Han, J, Shu, X, Das, B, Luby-Phelps, K, Krishna, UM, Broek, D
guanyl-nucleotide exchange factor activity of p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane]
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