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ICOS binds ICOSL/B7-H2
Stable Identifier
R-HSA-388817
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-stimulation by ICOS (Homo sapiens)
ICOS binds ICOSL/B7-H2 (Homo sapiens)
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Inducible T cell co-stimulatory (ICOS) protein is a critical positive co-stimulatory receptor in the CD28 family that enhances T cell activation and immune function. ICOS engages with its ligand, B7-H2 (ICOSL or B7RP-1), found on antigen-presenting cells. This interaction amplifies T cell responses by promoting cytokine production, cell proliferation, and prolonged T cell survival, playing a pivotal role in fine-tuning the immune response (Richter and Burdach 2004).
Literature References
PubMed ID
Title
Journal
Year
15870016
Regulation of immune and autoimmune responses by ICOS-B7h interaction
Nurieva, RI
Clin Immunol
2005
15007255
ICOS: a new costimulatory ligand/receptor pair and its role in T-cell activion
Burdach, S
,
Richter, G
Onkologie
2004
Participants
Input
ICOS-1 [plasma membrane]
(Homo sapiens)
ICOSLG [plasma membrane]
(Homo sapiens)
Output
ICOS:ICOSL [plasma membrane]
(Homo sapiens)
Entity On Other Cell
ICOSLG [plasma membrane]
(Homo sapiens)
Participates
as an event of
Co-stimulation by ICOS (Homo sapiens)
Orthologous Events
ICOS binds ICOSL/B7-H2 (Bos taurus)
ICOS binds ICOSL/B7-H2 (Canis familiaris)
ICOS binds ICOSL/B7-H2 (Gallus gallus)
ICOS binds ICOSL/B7-H2 (Mus musculus)
ICOS binds ICOSL/B7-H2 (Rattus norvegicus)
ICOS binds ICOSL/B7-H2 (Sus scrofa)
Authored
Garapati, P V (2008-12-16)
Reviewed
Bluestone, JA (2009-06-01)
Esensten, J (2009-06-01)
Created
Garapati, P V (2008-12-16)
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