ICOS binds ICOSL/B7-H2

Stable Identifier
R-HSA-388817
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Inducible T cell co-stimulatory (ICOS) protein is a critical positive co-stimulatory receptor in the CD28 family that enhances T cell activation and immune function. ICOS engages with its ligand, B7-H2 (ICOSL or B7RP-1), found on antigen-presenting cells. This interaction amplifies T cell responses by promoting cytokine production, cell proliferation, and prolonged T cell survival, playing a pivotal role in fine-tuning the immune response (Richter and Burdach 2004).
Literature References
PubMed ID Title Journal Year
15870016 Regulation of immune and autoimmune responses by ICOS-B7h interaction

Nurieva, RI

Clin Immunol 2005
15007255 ICOS: a new costimulatory ligand/receptor pair and its role in T-cell activion

Burdach, S, Richter, G

Onkologie 2004
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