POMC(138-176) binds MC2R

Stable Identifier
R-HSA-388605
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
ACTH binds MC2R
ReviewStatus
5/5
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MC2R (aka ACTH receptor) selectively binds POMC(138-176) (ACTH, corticotropin) (Gantz et al. 1993, Lee et al. 1961, Mountjoy et al. 1992). ACTH regulates adrenal cortical function via the G protein alpha-s subunit.
Literature References
PubMed ID Title Journal Year
1325670 The cloning of a family of genes that encode the melanocortin receptors

Robbins, LS, Cone, RD, Mortrud, MT, Mountjoy, KG

Science 1992
8463333 Molecular cloning of a novel melanocortin receptor

Gantz, I, Yamada, T, Shimoto, Y, Miwa, H, Tashiro, T, Konda, Y, Munzert, G, Watson, SJ, DelValle, J

J Biol Chem 1993
14463577 On the structure of human corticotropin (adrenocorticotropic hormone)

Lerner, AB, Buettner-Janusch, V, Lee, TH

J Biol Chem 1961
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