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MC2R [plasma membrane]
Stable Identifier
R-HSA-388600
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
RecName: Full=Adrenocorticotropic hormone receptor; Short=ACTH receptor; Short=ACTH-R; Short=Adrenocorticotropin receptor; AltName: Full=Melanocortin receptor 2; AltName: Full=MC2-R;
GN Name=MC2R; Synonyms=ACTHR;
OS Homo sapiens, ACTHR_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Defective ACTH causes obesity and POMCD (Homo sapiens)
Defective ACTH does not bind MCR2 (Homo sapiens)
MC2R [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
POMC(138-176):MC2R [plasma membrane] (Homo sapiens)
MC2R [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
POMC(138-176):MC2R [plasma membrane] (Homo sapiens)
MC2R [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
POMC(138-176):MC2R [plasma membrane] (Homo sapiens)
MC2R [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
POMC(138-176):MC2R [plasma membrane] (Homo sapiens)
MC2R [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
POMC(138-176):MC2R [plasma membrane] (Homo sapiens)
MC2R [plasma membrane] (Homo sapiens)
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
MC2R [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
POMC(138-176) binds MC2R (Homo sapiens)
MC2R [plasma membrane] (Homo sapiens)
POMC(138-176):MC2R [plasma membrane] (Homo sapiens)
MC2R [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01718 MC2R
Gene Names
MC2R, ACTHR
Chain
chain:1-297
Reference Genes
BioGPS Gene:4158 MC2R
COSMIC (genes):MC2R MC2R
CTD Gene:4158 MC2R
dbSNP Gene:4158 MC2R
ENSEMBL:ENSG00000185231.5 MC2R
HGNC:6930 MC2R
KEGG Gene (Homo sapiens):4158 MC2R
Monarch:4158 MC2R
NCBI Gene:4158 MC2R
OMIM:607397 MC2R
UCSC:Q01718 MC2R
Reference Transcript
RefSeq:NM_000529.2 MC2R
RefSeq:XM_017025781.1 MC2R
RefSeq:NM_001291911.1 MC2R
Other Identifiers
0003120494
11741169_at
11741170_at
11741171_at
16854097
208568_PM_at
208568_at
217434_PM_at
217434_at
3800117
3800118
3800119
3800120
4158
420_at
8022412
A_23_P38649
GE79781
GO:0004930
GO:0004977
GO:0004978
GO:0005515
GO:0005622
GO:0005737
GO:0005886
GO:0005887
GO:0007165
GO:0007186
GO:0007187
GO:0007189
GO:0007218
GO:0016020
GO:0016021
GO:0019222
GO:0023052
GO:0060089
HMNXSV003038925
Hs.274501.0.S1_3p_at
ILMN_1778521
PH_hs_0013164
PH_hs_0036685
TC18000382.hg
TC18000851.hg
X65633_at
g4505126_3p_at
Participates
as an input of
POMC(138-176) binds MC2R (Homo sapiens)
Defective ACTH does not bind MCR2 (Homo sapiens)
as a member of
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
as a component of
POMC(138-176):MC2R [plasma membrane] (Homo sapiens)
Inferred To
MC2R [plasma membrane]
(Bos taurus)
MC2R [plasma membrane]
(Canis familiaris)
MC2R [plasma membrane]
(Danio rerio)
MC2R [plasma membrane]
(Gallus gallus)
MC2R [plasma membrane]
(Sus scrofa)
MC2R [plasma membrane]
(Xenopus tropicalis)
Mc2r [plasma membrane]
(Mus musculus)
Mc2r [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_000520.1
,
NP_001278840.1
,
XP_016881270.1
Guide to Pharmacology - Targets
283
OpenTargets
ENSG00000185231
HPA
ENSG00000185231-MC2R
GeneCards
Q01718
Ensembl
ENST00000327606
,
ENSP00000333821
,
ENSG00000185231
ZINC target
Q01718
PRO
Q01718
Pharos - Targets
Q01718
Orphanet
16382
HMDB Protein
HMDBP12756
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8TCY5-1 MRAP
0.621
3
UniProt:Q96G30 MRAP2
0.573
2
UniProt:Q8TCY5 MRAP
0.573
3
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