Reactome | MC2R [plasma membrane]

MC2R [plasma membrane]

Stable Identifier

R-HSA-388600

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

RecName: Full=Adrenocorticotropic hormone receptor; Short=ACTH receptor; Short=ACTH-R; Short=Adrenocorticotropin receptor; AltName: Full=Melanocortin receptor 2; AltName: Full=MC2-R;
GN Name=MC2R; Synonyms=ACTHR;
OS Homo sapiens, ACTHR_HUMAN

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External Reference Information

External Reference

UniProt:Q01718 MC2R

Gene Names

MC2R, ACTHR

Chain

chain:1-297

Reference Genes

BioGPS Gene:4158 MC2R

COSMIC (genes):MC2R MC2R

CTD Gene:4158 MC2R

dbSNP Gene:4158 MC2R

ENSEMBL:ENSG00000185231 MC2R

HGNC:6930 MC2R

KEGG:hsa:4158 MC2R

Monarch:4158 MC2R

NCBI Gene:4158 MC2R

OMIM:607397 MC2R

UCSC:Q01718 MC2R

Reference Transcript

Other Identifiers

11741169_at

11741170_at

11741171_at

16854097

208568_PM_at

208568_at

217434_PM_at

217434_at

3800117

3800118

3800119

3800120

4158

420_at

8022412

A_23_P38649

GE79781

GO:0004930

GO:0004977

GO:0004978

GO:0005515

GO:0005737

GO:0005886

GO:0007165

GO:0007186

GO:0007187

GO:0007189

GO:0007218

GO:0016020

GO:0019222

GO:0060089

HMNXSV003038925

Hs.274501.0.S1_3p_at

ILMN_1778521

PH_hs_0013164

PH_hs_0036685

TC18000382.hg

TC18000851.hg

X65633_at

g4505126_3p_at

Participates

as an input of

as a member of

GPCRs that activate Gs [plasma membrane] (Homo sapiens)

as a component of

POMC(138-176):MC2R [plasma membrane] (Homo sapiens)

Inferred To

MC2R [plasma membrane] (Bos taurus)

MC2R [plasma membrane] (Canis familiaris)

MC2R [plasma membrane] (Gallus gallus)

MC2R [plasma membrane] (Sus scrofa)

Mc2r [plasma membrane] (Mus musculus)

Mc2r [plasma membrane] (Rattus norvegicus)

mc2r [plasma membrane] (Danio rerio)

Cross References

RefSeq

XP_016881270.1, NP_001278840.1, NP_000520.1

Guide to Pharmacology - Targets

283

ENSEMBL

ENST00000327606, ENSG00000185231, ENSP00000333821

OpenTargets

ENSG00000185231

ZINC - Substances

ACTHR_HUMAN

ZINC target

Q01718

PRO

Q01718

GlyGen

Q01718

PDB

8GY7

GeneCards

MC2R

HPA

ENSG00000185231-MC2R

Pharos - Targets

Q01718

Orphanet

MC2R

HMDB Protein

HMDBP12756

Interactors (3)

Accession	Confidence Score	Evidence (IntAct)
UniProt:Q8TCY5-1 MRAP	0.621	3
UniProt:Q96G30 MRAP2	0.573	2
UniProt:Q8TCY5 MRAP	0.573	3