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OXTR [plasma membrane]
Stable Identifier
R-HSA-388428
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Oxytocin receptor, RecName: Full=Oxytocin receptor; Short=OT-R;
GN Name=OXTR;
OS Homo sapiens, OXYR_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
OXTR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
OXTR [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
OXTR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
OXTR [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
OXTR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
OXTR [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Vasopressin-like receptors (Homo sapiens)
Oxytocin receptor bind oxytocin (Homo sapiens)
OXTR [plasma membrane] (Homo sapiens)
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
OXTR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30559 OXTR
Gene Names
OXTR
Chain
chain:1-389
Reference Genes
BioGPS Gene:5021 OXTR
COSMIC (genes):OXTR OXTR
CTD Gene:5021 OXTR
dbSNP Gene:5021 OXTR
ENSEMBL:ENSG00000180914 OXTR
ENSEMBL:ENSG00000180914.11 OXTR
HGNC:8529 OXTR
KEGG Gene (Homo sapiens):5021 OXTR
Monarch:5021 OXTR
NCBI Gene:5021 OXTR
OMIM:167055 OXTR
UCSC:P30559 OXTR
Reference Transcript
RefSeq:XM_011533762.2 OXTR
RefSeq:NM_000916.3 OXTR
Other Identifiers
11739389_at
11739390_at
16950440
206825_PM_at
206825_at
2661991
2661993
2661994
2661995
2661996
2661997
2661998
2662005
2662006
2662007
2662008
2662011
2662013
5021
8085138
A_23_P132619
A_24_P337104
A_33_P3413741
GE62407
GO:0001967
GO:0001975
GO:0001992
GO:0003012
GO:0003013
GO:0004930
GO:0004990
GO:0005000
GO:0005886
GO:0005902
GO:0005912
GO:0006936
GO:0007165
GO:0007166
GO:0007186
GO:0007204
GO:0007507
GO:0007565
GO:0007595
GO:0007613
GO:0009410
GO:0010701
GO:0014070
GO:0016020
GO:0016324
GO:0017046
GO:0021537
GO:0022414
GO:0023052
GO:0032230
GO:0032355
GO:0032570
GO:0032870
GO:0034059
GO:0034097
GO:0034330
GO:0035176
GO:0042220
GO:0042277
GO:0042711
GO:0042713
GO:0042755
GO:0043434
GO:0044849
GO:0045777
GO:0045907
GO:0048545
GO:0048565
GO:0048856
GO:0050877
GO:0050886
GO:0051965
GO:0051968
GO:0060089
GO:0060137
GO:0060406
GO:0070371
GO:0070474
GO:0120162
HMNXSV003016837
ILMN_1804929
PH_hs_0027544
TC03001145.hg
X64878_at
g12707575_3p_at
Participates
as an input of
Oxytocin receptor bind oxytocin (Homo sapiens)
as a member of
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
as a component of
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
Inferred To
Oxtr [plasma membrane]
(Mus musculus)
Oxtr [plasma membrane]
(Rattus norvegicus)
OXTR [plasma membrane]
(Bos taurus)
OXTR [plasma membrane]
(Canis familiaris)
OXTR [plasma membrane]
(Gallus gallus)
OXTR [plasma membrane]
(Sus scrofa)
oxtr [plasma membrane]
(Danio rerio)
oxtr [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
XP_011532064.1
,
NP_000907.2
ZINC - World Drugs
OXYR_HUMAN
Guide to Pharmacology - Targets
369
OpenTargets
ENSG00000180914
ZINC - Substances
OXYR_HUMAN
ZINC target
P30559
PRO
P30559
PDB
7RYC
,
6TPK
,
7QVM
ZINC - Investigational
OXYR_HUMAN
GeneCards
P30559
HPA
ENSG00000180914-OXTR
Ensembl
ENST00000316793
,
ENSG00000180914
,
ENSP00000324270
Pharos - Targets
P30559
Orphanet
24782
ZINC - Predictions - Purchasable
OXYR_HUMAN
HMDB Protein
HMDBP01957
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