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OXTR [plasma membrane]
Stable Identifier
R-HSA-388428
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Oxytocin receptor, RecName: Full=Oxytocin receptor; Short=OT-R;
GN Name=OXTR;
OS Homo sapiens, OXYR_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
OXTR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
OXTR [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
OXTR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
OXTR [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
OXTR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
OXTR [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Vasopressin-like receptors (Homo sapiens)
Oxytocin receptor bind oxytocin (Homo sapiens)
OXTR [plasma membrane] (Homo sapiens)
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
OXTR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30559 OXTR
Gene Names
OXTR
Chain
chain:1-389
Reference Genes
BioGPS Gene:5021 OXTR
COSMIC (genes):OXTR OXTR
CTD Gene:5021 OXTR
dbSNP Gene:5021 OXTR
ENSEMBL:ENSG00000180914 OXTR
HGNC:8529 OXTR
KEGG:hsa:5021 OXTR
Monarch:5021 OXTR
NCBI Entrez Gene:5021 OXTR
OMIM:167055 OXTR
UCSC:P30559 OXTR
Reference Transcript
RefSeq:NM_001354656.3 OXTR
RefSeq:NM_001354654.2 OXTR
RefSeq:NM_001354653.2 OXTR
RefSeq:NM_001354655.2 OXTR
RefSeq:NM_000916.3 OXTR
RefSeq:XM_011533762.2 OXTR
Other Identifiers
11739389_at
11739390_at
16950440
206825_PM_at
206825_at
2661991
2661993
2661994
2661995
2661996
2661997
2661998
2662004
2662005
2662006
2662007
2662008
2662009
2662010
2662011
2662012
2662013
5021
8085138
A_23_P132619
A_24_P337104
A_33_P3413741
GE62407
GO:0001992
GO:0003008
GO:0003012
GO:0003013
GO:0004930
GO:0004990
GO:0005000
GO:0005886
GO:0006936
GO:0007165
GO:0007166
GO:0007186
GO:0007565
GO:0007595
GO:0016020
GO:0022414
GO:0032870
GO:0045777
GO:0045907
GO:0050886
GO:0060137
GO:0065008
GO:0120162
HMNXSV003016837
ILMN_1804929
PH_hs_0027544
TC03001145.hg
X64878_at
g12707575_3p_at
Participates
as an input of
Oxytocin receptor bind oxytocin (Homo sapiens)
as a member of
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
as a component of
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
Inferred To
Oxtr [plasma membrane]
(Mus musculus)
Oxtr [plasma membrane]
(Rattus norvegicus)
OXTR [plasma membrane]
(Bos taurus)
OXTR [plasma membrane]
(Canis familiaris)
OXTR [plasma membrane]
(Gallus gallus)
OXTR [plasma membrane]
(Sus scrofa)
oxtr [plasma membrane]
(Xenopus tropicalis)
oxtra [plasma membrane]
(Danio rerio)
Cross References
RefSeq
NP_001341583.1
,
XP_011532064.1
,
NP_001341582.1
,
NP_000907.2
,
NP_001341584.1
,
NP_001341585.1
ZINC - World Drugs
OXYR_HUMAN
Guide to Pharmacology - Targets
369
ENSEMBL
ENST00000316793
,
ENSG00000180914
,
ENSP00000324270
OpenTargets
ENSG00000180914
ZINC - Substances
OXYR_HUMAN
ZINC target
P30559
PRO
P30559
GlyGen
P30559
PDB
6TPK
,
7QVM
,
7RYC
ZINC - Investigational
OXYR_HUMAN
GeneCards
OXTR
HPA
ENSG00000180914-OXTR
Pharos - Targets
P30559
ZINC - Predictions - Purchasable
OXYR_HUMAN
HMDB Protein
HMDBP01957
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