Reactome | RAP1A exchanges GDP for GTP

RAP1A exchanges GDP for GTP

Stable Identifier

R-HSA-381727

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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EPAC1 and EPAC2 are activated by binding cAMP and positively regulate the exchange of GDP for GTP by the small GTPase RAP1A. The downstream effects of RAP1A:GTP in beta cells are uncertain but may involve increasing the number of "restless newcomer" secretory granules near the plasma membrane and thereby increasing secretion of insulin.
Other effects of RAP1A :GTP may include regulating beta cell proliferation through activation of the Raf/MEK/ERK mitogenic cascade and activation of the PI3 Kinase/PDK/PKC cell growth pathway.

Literature References

PubMed ID	Title	Journal	Year
15569269	Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential Gromada, J, Brock, B, Schmitz, O, Rorsman, P	Basic Clin Pharmacol Toxicol	2004
16973695	Cell physiology of cAMP sensor Epac Holz, GG, Kang, G, Harbeck, M, Roe, MW, Chepurny, OG	J Physiol	2006
15995848	The Rap-B-Raf signalling pathway is activated by glucose and glucagon-like peptide-1 in human islet cells Trümper, J, Ross, D, Jahr, H, Brendel, MD, Göke, R, Hörsch, D	Diabetologia	2005
17306374	Mechanisms of action of glucagon-like peptide 1 in the pancreas Doyle, ME, Egan, JM	Pharmacol Ther	2007