RAP1A exchanges GDP for GTP

Stable Identifier
R-HSA-381727
Type
Reaction [transition]
Species
Homo sapiens
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EPAC1 and EPAC2 are activated by binding cAMP and positively regulate the exchange of GDP for GTP by the small GTPase RAP1A. The downstream effects of RAP1A:GTP in beta cells are uncertain but may involve increasing the number of "restless newcomer" secretory granules near the plasma membrane and thereby increasing secretion of insulin.
Other effects of RAP1A :GTP may include regulating beta cell proliferation through activation of the Raf/MEK/ERK mitogenic cascade and activation of the PI3 Kinase/PDK/PKC cell growth pathway.

Literature References
PubMed ID Title Journal Year
16973695 Cell physiology of cAMP sensor Epac

Holz, GG, Kang, G, Harbeck, M, Roe, MW, Chepurny, OG

J Physiol 2006
15569269 Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential

Gromada, J, Brock, B, Schmitz, O, Rorsman, P

Basic Clin Pharmacol Toxicol 2004
15995848 The Rap-B-Raf signalling pathway is activated by glucose and glucagon-like peptide-1 in human islet cells

Trümper, J, Ross, D, Jahr, H, Brendel, MD, Göke, R, Hörsch, D

Diabetologia 2005
17306374 Mechanisms of action of glucagon-like peptide 1 in the pancreas

Doyle, ME, Egan, JM

Pharmacol Ther 2007
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