Reactome | ER calcium channels open in response to activated PKA

ER calcium channels open in response to activated PKA

Stable Identifier

R-HSA-381644

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

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ER calcium channels open in response to activated PKA

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Activated Protein Kinase A promotes the release of calcium from the endoplasmic reticulum into the cytosol. This may be due to phosphorylation of ER calcium channels by PKA, however this has not been demonstrated.

Literature References

PubMed ID	Title	Journal	Year
10318832	cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37) Holz, GG, Leech, CA, Heller, RS, Castonguay, M, Habener, JF	J Biol Chem	1999
12410638	Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells Tsuboi, T, da Silva Xavier, G, Holz, GG, Jouaville, LS, Thomas, AP, Rutter, GA	Biochem J	2003
15569269	Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential Gromada, J, Brock, B, Schmitz, O, Rorsman, P	Basic Clin Pharmacol Toxicol	2004
8830891	Molecular mechanism underlying glucagon-like peptide 1 induced calcium mobilization from internal stores in insulin-secreting beta TC3 cells Gromada, J, Rorsman, P	Acta Physiol Scand	1996
9488697	Phosphorylation of inositol 1,4,5-trisphosphate receptors by cAMP-dependent protein kinase. Type I, II, and III receptors are differentially susceptible to phosphorylation and are phosphorylated in intact cells Wojcikiewicz, RJ, Luo, SG	J Biol Chem	1998
12475787	The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion MacDonald, PE, El-Kholy, W, Riedel, MJ, Salapatek, AM, Light, PE, Wheeler, MB	Diabetes	2002
17306374	Mechanisms of action of glucagon-like peptide 1 in the pancreas Doyle, ME, Egan, JM	Pharmacol Ther	2007