Potassium voltage-gated channels (beta cell, open)

Stable Identifier
R-HSA-381640
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Human pancreatic beta cells contain Kv2.1, Kv3.2, Kv6.2, and Kv9.3 voltage gated potassium channels. The channels are closed in a resting beta and channels open in response to depolarization. Open channels counteract the effect of closed ATP-gated potassium channels and thereby end stimulation of insulin secretion .

Literature References
PubMed ID Title Journal Year
14988243 Expression of voltage-gated potassium channels in human and rhesus pancreatic islets

Yan, L, Figueroa, DJ, Austin, CP, Liu, Y, Bugianesi, RM, Slaughter, RS, Kaczorowski, GJ, Kohler, MG

Diabetes 2004
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