Reactome | Potassium voltage-gated channels close in reponse to PKA

Potassium voltage-gated channels close in reponse to PKA

Stable Identifier

R-HSA-381713

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Potassium voltage-gated channels close in reponse to PKA

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Protein kinase A acts to antagonize voltage-gated potassium channels (Kv channels) by increasing the polarizing voltage required to open them. Maintenance of the Kv channels in the closed state prolongs depolarization and insulin secretion. The exact mechanism of the interaction between PKA and the Kv channels is unknown.

Literature References

PubMed ID	Title	Journal	Year
15569269	Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential Gromada, J, Brock, B, Schmitz, O, Rorsman, P	Basic Clin Pharmacol Toxicol	2004
14988243	Expression of voltage-gated potassium channels in human and rhesus pancreatic islets Yan, L, Figueroa, DJ, Austin, CP, Liu, Y, Bugianesi, RM, Slaughter, RS, Kaczorowski, GJ, Kohler, MG	Diabetes	2004
12475787	The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion MacDonald, PE, El-Kholy, W, Riedel, MJ, Salapatek, AM, Light, PE, Wheeler, MB	Diabetes	2002
15955806	A novel mechanism for the suppression of a voltage-gated potassium channel by glucose-dependent insulinotropic polypeptide: protein kinase A-dependent endocytosis Kim, SJ, Choi, WS, Han, JS, Warnock, G, Fedida, D, McIntosh, CH	J Biol Chem	2005
17306374	Mechanisms of action of glucagon-like peptide 1 in the pancreas Doyle, ME, Egan, JM	Pharmacol Ther	2007