Potassium voltage-gated channels close in reponse to PKA

Stable Identifier
R-HSA-381713
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Protein kinase A acts to antagonize voltage-gated potassium channels (Kv channels) by increasing the polarizing voltage required to open them. Maintenance of the Kv channels in the closed state prolongs depolarization and insulin secretion. The exact mechanism of the interaction between PKA and the Kv channels is unknown.

Literature References
PubMed ID Title Journal Year
14988243 Expression of voltage-gated potassium channels in human and rhesus pancreatic islets

Yan, L, Figueroa, DJ, Austin, CP, Liu, Y, Bugianesi, RM, Slaughter, RS, Kaczorowski, GJ, Kohler, MG

Diabetes 2004
15569269 Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential

Gromada, J, Brock, B, Schmitz, O, Rorsman, P

Basic Clin Pharmacol Toxicol 2004
12475787 The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion

MacDonald, PE, El-Kholy, W, Riedel, MJ, Salapatek, AM, Light, PE, Wheeler, MB

Diabetes 2002
15955806 A novel mechanism for the suppression of a voltage-gated potassium channel by glucose-dependent insulinotropic polypeptide: protein kinase A-dependent endocytosis

Kim, SJ, Choi, WS, Han, JS, Warnock, G, Fedida, D, McIntosh, CH

J Biol Chem 2005
17306374 Mechanisms of action of glucagon-like peptide 1 in the pancreas

Doyle, ME, Egan, JM

Pharmacol Ther 2007
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