Reactome | PAAP-A proteolyzes IGF:IGFBP4

PAAP-A proteolyzes IGF:IGFBP4

Stable Identifier

R-HSA-381518

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Pregnancy associated Plasma Protein A (PPAP-A) cleaves IGFBP-4 in the IGF:IGFBP-4 Complex between amino acids 156 and 157, releasing IGF.

Literature References

PubMed ID	Title	Journal	Year
17249697	Quantitative analysis of insulin-like growth factor-modulated proteolysis of insulin-like growth factor binding protein-4 and -5 by pregnancy-associated plasma protein-A Gyrup, C, Oxvig, C	Biochemistry	2007
12466191	Cellular actions of the insulin-like growth factor binding proteins Firth, SM, Baxter, RC	Endocr Rev	2002
17047378	The role of insulin-like growth factor binding proteins Holly, J, Perks, C	Neuroendocrinology	2006
10077652	The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A Lawrence, JB, Oxvig, C, Overgaard, MT, Sottrup-Jensen, L, Gleich, GJ, Hays, LG, Yates, JR 3rd, Conover, CA	Proc Natl Acad Sci U S A	1999
12379487	IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms Mohan, S, Baylink, DJ	J Endocrinol	2002
17312271	Regulation of insulin-like growth factor (IGF) bioactivity by sequential proteolytic cleavage of IGF binding protein-4 and -5 Laursen, LS, Kjaer-Sorensen, K, Andersen, MH, Oxvig, C	Mol Endocrinol	2007
12241545	Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysis Laursen, LS, Overgaard, MT, Nielsen, CG, Boldt, HB, Hopmann, KH, Conover, CA, Sottrup-Jensen, L, Giudice, LC, Oxvig, C	Biochem J	2002
11158056	Pregnancy-associated plasma protein-A accounts for the insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) proteolytic activity in human pregnancy serum and enhances the mitogenic activity of IGF by degrading IGFBP-4 in vitro Byun, D, Mohan, S, Yoo, M, Sexton, C, Baylink, DJ, Qin, X	J Clin Endocrinol Metab	2001
10898936	Evidence that the interaction between insulin-like growth factor (IGF)-II and IGF binding protein (IGFBP)-4 is essential for the action of the IGF-II-dependent IGFBP-4 protease Qin, X, Byun, D, Lau, KH, Baylink, DJ, Mohan, S	Arch Biochem Biophys	2000
12904166	IGF-binding protein-4: biochemical characteristics and functional consequences Zhou, R, Diehl, D, Hoeflich, A, Lahm, H, Wolf, E	J Endocrinol	2003