PAAP-A proteolyzes IGF:IGFBP4

Stable Identifier
R-HSA-381518
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Pregnancy associated Plasma Protein A (PPAP-A) cleaves IGFBP-4 in the IGF:IGFBP-4 Complex between amino acids 156 and 157, releasing IGF.

Literature References
PubMed ID Title Journal Year
12466191 Cellular actions of the insulin-like growth factor binding proteins

Firth, SM, Baxter, RC

Endocr Rev 2002
17249697 Quantitative analysis of insulin-like growth factor-modulated proteolysis of insulin-like growth factor binding protein-4 and -5 by pregnancy-associated plasma protein-A

Gyrup, C, Oxvig, C

Biochemistry 2007
17047378 The role of insulin-like growth factor binding proteins

Holly, J, Perks, C

Neuroendocrinology 2006
10077652 The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A

Lawrence, JB, Oxvig, C, Overgaard, MT, Sottrup-Jensen, L, Gleich, GJ, Hays, LG, Yates, JR 3rd, Conover, CA

Proc Natl Acad Sci U S A 1999
12379487 IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms

Mohan, S, Baylink, DJ

J Endocrinol 2002
17312271 Regulation of insulin-like growth factor (IGF) bioactivity by sequential proteolytic cleavage of IGF binding protein-4 and -5

Laursen, LS, Kjaer-Sorensen, K, Andersen, MH, Oxvig, C

Mol Endocrinol 2007
12241545 Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysis

Laursen, LS, Overgaard, MT, Nielsen, CG, Boldt, HB, Hopmann, KH, Conover, CA, Sottrup-Jensen, L, Giudice, LC, Oxvig, C

Biochem J 2002
11158056 Pregnancy-associated plasma protein-A accounts for the insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) proteolytic activity in human pregnancy serum and enhances the mitogenic activity of IGF by degrading IGFBP-4 in vitro

Byun, D, Mohan, S, Yoo, M, Sexton, C, Baylink, DJ, Qin, X

J Clin Endocrinol Metab 2001
10898936 Evidence that the interaction between insulin-like growth factor (IGF)-II and IGF binding protein (IGFBP)-4 is essential for the action of the IGF-II-dependent IGFBP-4 protease

Qin, X, Byun, D, Lau, KH, Baylink, DJ, Mohan, S

Arch Biochem Biophys 2000
12904166 IGF-binding protein-4: biochemical characteristics and functional consequences

Zhou, R, Diehl, D, Hoeflich, A, Lahm, H, Wolf, E

J Endocrinol 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
metalloendopeptidase activity of PAPPA,PAPPA2 [extracellular region]
Physical Entity
Activity
Orthologous Events
Reviewed
Created