PAAP-A proteolyzes IGF:IGFBP4

Stable Identifier
Reaction [transition]
Homo sapiens
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Pregnancy associated Plasma Protein A (PPAP-A) cleaves IGFBP-4 in the IGF:IGFBP-4 Complex between amino acids 156 and 157, releasing IGF.
Literature References
PubMed ID Title Journal Year
17249697 Quantitative analysis of insulin-like growth factor-modulated proteolysis of insulin-like growth factor binding protein-4 and -5 by pregnancy-associated plasma protein-A

Oxvig, C, Gyrup, C

Biochemistry 2007
12466191 Cellular actions of the insulin-like growth factor binding proteins

Baxter, RC, Firth, SM

Endocr Rev 2002
17047378 The role of insulin-like growth factor binding proteins

Perks, C, Holly, J

Neuroendocrinology 2006
10077652 The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A

Conover, CA, Sottrup-Jensen, L, Yates, JR 3rd, Overgaard, MT, Lawrence, JB, Oxvig, C, Gleich, GJ, Hays, LG

Proc Natl Acad Sci U S A 1999
12379487 IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms

Mohan, S, Baylink, DJ

J Endocrinol 2002
17312271 Regulation of insulin-like growth factor (IGF) bioactivity by sequential proteolytic cleavage of IGF binding protein-4 and -5

Andersen, MH, Kjaer-Sorensen, K, Oxvig, C, Laursen, LS

Mol Endocrinol 2007
12241545 Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysis

Conover, CA, Sottrup-Jensen, L, Overgaard, MT, Boldt, HB, Oxvig, C, Laursen, LS, Hopmann, KH, Nielsen, CG, Giudice, LC

Biochem J 2002
11158056 Pregnancy-associated plasma protein-A accounts for the insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) proteolytic activity in human pregnancy serum and enhances the mitogenic activity of IGF by degrading IGFBP-4 in vitro

Mohan, S, Sexton, C, Baylink, DJ, Byun, D, Qin, X, Yoo, M

J Clin Endocrinol Metab 2001
10898936 Evidence that the interaction between insulin-like growth factor (IGF)-II and IGF binding protein (IGFBP)-4 is essential for the action of the IGF-II-dependent IGFBP-4 protease

Lau, KH, Mohan, S, Baylink, DJ, Byun, D, Qin, X

Arch Biochem Biophys 2000
12904166 IGF-binding protein-4: biochemical characteristics and functional consequences

Wolf, E, Lahm, H, Zhou, R, Hoeflich, A, Diehl, D

J Endocrinol 2003
Catalyst Activity

metalloendopeptidase activity of PAPPA,PAPPA2 [extracellular region]

Orthologous Events
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