IGFBP1 binds IGF forming IGF:IGFBP1

Stable Identifier
Reaction [binding]
Homo sapiens
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IGFBP 1 binds IGF I or IGF II via the conserved N terminus and C terminus of IGFBP 1. IGFBP 1 is enriched in amniotic fluid and is produced in the liver under control of insulin (insulin suppresses production). IGFBP 1 acts to stimulate IGF function. It is unknown which if any protease degrades IGFBP 1.
Literature References
PubMed ID Title Journal Year
7543116 Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation

Hall, K, Skakkebaek, NE, Müller, J, Blum, WF, Michaelsen, KF, Bang, P, Dalgaard, P, Juul, A

J Clin Endocrinol Metab 1995
7683646 Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6

Hsieh, S, Sakano, K, Rechler, MM, Fujiwara, H, Bach, LA, Perdue, JF

J Biol Chem 1993
12466191 Cellular actions of the insulin-like growth factor binding proteins

Baxter, RC, Firth, SM

Endocr Rev 2002
17047378 The role of insulin-like growth factor binding proteins

Perks, C, Holly, J

Neuroendocrinology 2006
7689487 Glucose does not influence the insulin-like growth factor (JGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting

Savage, MO, Holly, JM, Frost, VJ, Cianfarani, S

Experientia 1993
12379487 IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms

Mohan, S, Baylink, DJ

J Endocrinol 2002
9733769 The insulin-like growth factor (IGF)binding protein 1 binding epitope on IGF-I probed by heteronuclear NMR spectroscopy and mutational analysis

Nilsson, B, Kördel, J, Andersson, G, Jansson, M, Uhlén, M

J Biol Chem 1998
8781553 Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography

Rechler, MM, Bach, LA

Biochim Biophys Acta 1996
7519608 Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes

Arai, T, Busby W, Jr, Parker, A, Clemmons, DR

J Biol Chem 1994
Orthologous Events
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