IGFBP1 binds IGF forming IGF:IGFBP1

Stable Identifier
R-HSA-381487
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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IGFBP 1 binds IGF I or IGF II via the conserved N terminus and C terminus of IGFBP 1. IGFBP 1 is enriched in amniotic fluid and is produced in the liver under control of insulin (insulin suppresses production). IGFBP 1 acts to stimulate IGF function. It is unknown which if any protease degrades IGFBP 1.

Literature References
PubMed ID Title Journal Year
7683646 Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6

Bach, LA, Hsieh, S, Sakano, K, Fujiwara, H, Perdue, JF, Rechler, MM

J Biol Chem 1993
7543116 Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation

Juul, A, Dalgaard, P, Blum, WF, Bang, P, Hall, K, Michaelsen, KF, Müller, J, Skakkebaek, NE

J Clin Endocrinol Metab 1995
12466191 Cellular actions of the insulin-like growth factor binding proteins

Firth, SM, Baxter, RC

Endocr Rev 2002
17047378 The role of insulin-like growth factor binding proteins

Holly, J, Perks, C

Neuroendocrinology 2006
7689487 Glucose does not influence the insulin-like growth factor (JGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting

Cianfarani, S, Frost, VJ, Savage, MO, Holly, JM

Experientia 1993
12379487 IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms

Mohan, S, Baylink, DJ

J Endocrinol 2002
9733769 The insulin-like growth factor (IGF)binding protein 1 binding epitope on IGF-I probed by heteronuclear NMR spectroscopy and mutational analysis

Jansson, M, Andersson, G, Uhlén, M, Nilsson, B, Kördel, J

J Biol Chem 1998
8781553 Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography

Bach, LA, Rechler, MM

Biochim Biophys Acta 1996
7519608 Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes

Arai, T, Parker, A, Busby W, Jr, Clemmons, DR

J Biol Chem 1994
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