Reactome | IRE1 dimer [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-381200

Type

Complex

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Locations in the PathwayBrowser

Expand all

General

Crystallographic evidence indicates that the IRE1 homodimer forms by an initial interaction between the luminal N-terminal domains of IRE1 monomers.

Literature References

PubMed ID	Title	Journal	Year
11069889	The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response Tirasophon, W, Lee, K, Callaghan, B, Welihinda, A, Kaufman, RJ	Genes Dev	2000
16973740	The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response Zhou, J, Liu, CY, Back, SH, Clark, RL, Peisach, D, Xu, Z, Kaufman, RJ	Proc Natl Acad Sci U S A	2006
9637683	A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells Tirasophon, W, Welihinda, AA, Kaufman, RJ	Genes Dev	1998