Reactome | Dissociation of PERK:BiP Heterodimer

Dissociation of PERK:BiP Heterodimer

Stable Identifier

R-HSA-381086

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum lumen

ReviewStatus

5/5

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PERK (EIF2AK3) is a single-pass transmembrane protein located in the Endoplasmic Reticulum (ER) membrane. PERK has an N-terminal luminal domain and a C-terminal cytosolic domain. It is maintained in an inactive state by association of its luminal domain with BiP, a chaperone in the ER. Because BiP also binds unfolded proteins, BiP dissociates from PERK when unfolded proteins exceed chaperone activity in the ER.

Literature References

PubMed ID	Title	Journal	Year
17956313	PERK in the life and death of the pancreatic beta-cell Herbert, TP	Biochem Soc Trans	2007
11907036	Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress Wek, RC, Vattem, KM, Ma, K	J Biol Chem	2002

Participants

Input

Output

Participates

as an event of

PERK regulates gene expression (Homo sapiens)

Authored

May, B (2009-06-02)

Reviewed

Gillespie, ME (2008-12-02)

D'Eustachio, P (2008-12-02)

Matthews, L (2008-12-02)

Urano, F (2010-04-30)

Created

May, B (2008-11-19)

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