Dissociation of PERK:BiP Heterodimer

Stable Identifier
R-HSA-381086
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

PERK (EIF2AK3) is a single-pass transmembrane protein located in the Endoplasmic Reticulum (ER) membrane. PERK has an N-terminal luminal domain and a C-terminal cytosolic domain. It is maintained in an inactive state by association of its luminal domain with BiP, a chaperone in the ER. Because BiP also binds unfolded proteins, BiP dissociates from PERK when unfolded proteins exceed chaperone activity in the ER.

Literature References
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