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unfolded protein [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-381130
Type
Genes and Transcripts [GenomeEncodedEntity]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
ATF6 (ATF6-alpha) activates chaperones (Homo sapiens)
ATF6:HSPA5 (ATF6-alpha:BiP) dissociates and HSPA5 binds unfolded protein (Homo sapiens)
BiP:Unfolded Protein [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
ATF6B (ATF6-beta) activates chaperones (Homo sapiens)
ATF6B:HSPA5 (ATF6-beta:BiP) dissociates and HSPA5 binds unfolded protein (Homo sapiens)
BiP:Unfolded Protein [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
IRE1alpha activates chaperones (Homo sapiens)
IRE1:BiP dissociates in response to unfolded protein (Homo sapiens)
BiP:Unfolded Protein [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
PERK regulates gene expression (Homo sapiens)
Dissociation of PERK:BiP Heterodimer (Homo sapiens)
BiP:Unfolded Protein [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with N-glycosylation of proteins (Homo sapiens)
Defective MOGS causes CDG-2b (Homo sapiens)
Defective MOGS does not cleave glucose from an N-glycosylated protein (Homo sapiens)
unfolded protein:(Glc)3 (GlcNAc)2 (Man)9 (Asn)1 [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Homo sapiens)
Binding of Malectin (Homo sapiens)
unfolded protein:(Glc)2 (GlcNAc)2 (Man)9 (Asn)1 [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein:(Glc)2 (GlcNAc)2 (Man)9 (Asn)1:malectin [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein:(Glc)2 (GlcNAc)2 (Man)9 (Asn)1 [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
Calnexin/calreticulin cycle (Homo sapiens)
Binding of ERp57 (Homo sapiens)
unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 (Asn)1:chaperone [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 (Asn)1 [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 (Asn)1:chaperone:ERp57 [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 (Asn)1:chaperone [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 (Asn)1 [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
Binding of calnexin/calreticulin to the unfolded protein (Homo sapiens)
unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 (Asn)1 [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 (Asn)1:chaperone [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 (Asn)1 [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
ER Quality Control Compartment (ERQC) (Homo sapiens)
Glycoproteins with lesser folding defects get transported back to the ER and the CNX/CRT complex (Homo sapiens)
unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 (Asn)1 [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
Incorrectly folded glycoproteins translocate to the ERQC (Homo sapiens)
(un)folded protein:(GlcNAc)2 (Man)9 [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
Removal of the third glucose by glucosidase II and release from the chaperone (Homo sapiens)
unfolded protein:glycan (no glucose) [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein:glycan:chaperone:ERp57 [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein:glycan [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
Removal of the second glucose by glucosidase II (Homo sapiens)
unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 (Asn)1 [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein:(Glc)2 (GlcNAc)2 (Man)9 (Asn)1:malectin [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein:(Glc)2 (GlcNAc)2 (Man)9 (Asn)1 [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
Trimming of the first glucose by by mannosyl-oligosaccharide glucosidase (Homo sapiens)
unfolded protein:(Glc)2 (GlcNAc)2 (Man)9 (Asn)1 [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein:(Glc)3 (GlcNAc)2 (Man)9 (Asn)1 [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
Transfer of N-glycan to the protein (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein:(Glc)3 (GlcNAc)2 (Man)9 (Asn)1 [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
Correctly folded glycoproteins translocate to the Golgi (Homo sapiens)
(un)folded protein:(GlcNAc)2 (Man)9 [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein [endoplasmic reticulum lumen] (Homo sapiens)
Participates
as an input of
IRE1:BiP dissociates in response to unfolded protein (Homo sapiens)
ATF6B:HSPA5 (ATF6-beta:BiP) dissociates and HSPA5 binds unfolded protein (Homo sapiens)
ATF6:HSPA5 (ATF6-alpha:BiP) dissociates and HSPA5 binds unfolded protein (Homo sapiens)
Dissociation of PERK:BiP Heterodimer (Homo sapiens)
Transfer of N-glycan to the protein (Homo sapiens)
as a component of
BiP:Unfolded Protein [endoplasmic reticulum lumen] (Homo sapiens)
(un)folded protein:(GlcNAc)2 (Man)9 [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein:glycan (no glucose) [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein:glycan [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 (Asn)1 [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein:(Glc)3 (GlcNAc)2 (Man)9 (Asn)1 [endoplasmic reticulum lumen] (Homo sapiens)
unfolded protein:(Glc)2 (GlcNAc)2 (Man)9 (Asn)1 [endoplasmic reticulum lumen] (Homo sapiens)
Inferred To
Ghost homologue of unfolded protein [endoplasmic reticulum lumen]
(Bos taurus)
Ghost homologue of unfolded protein [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
Ghost homologue of unfolded protein [endoplasmic reticulum lumen]
(Canis familiaris)
Ghost homologue of unfolded protein [endoplasmic reticulum lumen]
(Danio rerio)
Ghost homologue of unfolded protein [endoplasmic reticulum lumen]
(Dictyostelium discoideum)
Ghost homologue of unfolded protein [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Ghost homologue of unfolded protein [endoplasmic reticulum lumen]
(Gallus gallus)
Ghost homologue of unfolded protein [endoplasmic reticulum lumen]
(Mus musculus)
Ghost homologue of unfolded protein [endoplasmic reticulum lumen]
(Rattus norvegicus)
Ghost homologue of unfolded protein [endoplasmic reticulum lumen]
(Saccharomyces cerevisiae)
Ghost homologue of unfolded protein [endoplasmic reticulum lumen]
(Schizosaccharomyces pombe)
Ghost homologue of unfolded protein [endoplasmic reticulum lumen]
(Sus scrofa)
Ghost homologue of unfolded protein [endoplasmic reticulum lumen]
(Xenopus tropicalis)
Cross References
ChEBI
36080
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