Reactome | ODF2 [cytosol]

ODF2 [cytosol]

Stable Identifier

R-HSA-380293

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        ODF2 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        ODF2 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        ODF2 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        ODF2 [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        ODF2 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        ODF2 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        ODF2 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        ODF2 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        ODF2 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        ODF2 [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        ODF2 [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        ODF2 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        ODF2 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        ODF2 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        ODF2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q5BJF6 ODF2

Gene Names

ODF2

Chain

chain:1-829

Reference Genes

BioGPS Gene:4957 ODF2

COSMIC (genes):ODF2 ODF2

CTD Gene:4957 ODF2

dbSNP Gene:4957 ODF2

ENSEMBL:ENSG00000136811 ODF2

HGNC:8114 ODF2

KEGG Gene (Homo sapiens):4957 ODF2

Monarch:4957 ODF2

NCBI Gene:4957 ODF2

OMIM:602015 ODF2

UCSC:Q5BJF6 ODF2

Reference Transcript

Other Identifiers

0002260204

0003710670

0005420132

11745067_a_at

11746212_a_at

11749149_a_at

11751734_a_at

17089667

210415_s_at

225617_at

3190464

3190465

3190466

3190467

3190468

3190469

3190471

3190472

3190473

3190474

3190475

3190476

3190477

3190478

3190479

3190482

3190483

3190484

3190486

3190488

3190489

3190490

3190492

3190493

3190495

3190497

3190498

3190499

3190500

3190501

3190503

3190506

3190507

3190509

3190510

3190511

3190513

41068_at

4957

53791_at

8158269

91980_at

A_14_P138694

A_21_P0000203

A_23_P60488

A_23_P71889

GO:0000003

GO:0000086

GO:0000278

GO:0000922

GO:0001520

GO:0003674

GO:0005198

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0005874

GO:0005929

GO:0007010

GO:0007049

GO:0007275

GO:0007283

GO:0007286

GO:0008104

GO:0008150

GO:0010389

GO:0010457

GO:0019899

GO:0022607

GO:0030154

GO:0031267

GO:0031514

GO:0032991

GO:0036064

GO:0036126

GO:0042995

GO:0043226

GO:0044782

GO:0048856

GO:0097539

GO:0097711

GO:0120103

GO:1902017

HMNXSV003004088

HMNXSV003015756

HMNXSV003028143

Hs.129055.2.S1_3p_at

ILMN_1671288

ILMN_1698653

ILMN_1730698

PH_hs_0007503

TC09000691.hg

g2996005_3p_a_at

Participates

as a component of

Inferred To

odf2 [cytosol] (Xenopus tropicalis)

ODF2 [cytosol] (Canis familiaris)

ODF2 [cytosol] (Gallus gallus)

ODF2 [cytosol] (Sus scrofa)

Odf2 [cytosol] (Mus musculus)

Odf2 [cytosol] (Rattus norvegicus)

odf2a [cytosol] (Danio rerio)

Cross References

RefSeq

XP_016870262.1, XP_006717189.1, NP_001229283.1, XP_016870266.1, NP_702914.1, NP_002531.3, XP_016870265.1, NP_702915.1, XP_016870261.1, NP_702913.1, NP_001229282.1, NP_702910.1, XP_016870264.1, NP_001229281.1, XP_016870263.1, NP_702911.1

OpenTargets

ENSG00000136811

HPA

ENSG00000136811-ODF2

GeneCards

Q5BJF6

Ensembl

ENSP00000361877, ENST00000372814, ENST00000393533, ENSP00000403453, ENSP00000377166, ENST00000434106, ENSP00000361901, ENSP00000377161, ENST00000372807, ENST00000546203, ENST00000351030, ENSP00000342581, ENSP00000394506, ENST00000372791, ENSP00000473949, ENSP00000437579, ENSP00000361893, ENSG00000136811, ENSP00000396687, ENST00000604420, ENST00000393527, ENST00000448249, ENST00000444119

PRO

Q5BJF6

Pharos - Targets

Q5BJF6

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