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TACR3 [plasma membrane]
Stable Identifier
R-HSA-380132
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Neuromedin K receptor, NK3 receptor, NK3R_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TACR3:TAC3 [plasma membrane] (Homo sapiens)
TACR3 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TACR3:TAC3 [plasma membrane] (Homo sapiens)
TACR3 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TACR3:TAC3 [plasma membrane] (Homo sapiens)
TACR3 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TACR3:TAC3 [plasma membrane] (Homo sapiens)
TACR3 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
TACR3 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TACR3:TAC3 [plasma membrane] (Homo sapiens)
TACR3 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Tachykinin receptors bind tachykinins (Homo sapiens)
Tachykinin receptor 3 (NK3) binds to neurokinin B (Homo sapiens)
TACR3 [plasma membrane] (Homo sapiens)
TACR3:TAC3 [plasma membrane] (Homo sapiens)
TACR3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29371 TACR3
Gene Names
TACR3, NK3R, TAC3R
Chain
chain:1-465
Reference Genes
BioGPS Gene:6870 TACR3
COSMIC (genes):TACR3 TACR3
CTD Gene:6870 TACR3
dbSNP Gene:6870 TACR3
ENSEMBL:ENSG00000169836 TACR3
ENSEMBL_homo_sapiens_GENE:ENSG00000169836.5 TACR3
HGNC:11528 TACR3
KEGG Gene (Homo sapiens):6870 TACR3
Monarch:6870 TACR3
NCBI Gene:6870 TACR3
OMIM:162332 TACR3
UCSC:P29371 TACR3
Reference Transcript
RefSeq:NM_001059.2 TACR3
Other Identifiers
11737293_at
16978631
208183_PM_at
208183_at
2780295
2780297
2780298
2780299
2780300
2780305
2780306
2780307
2780310
2780311
32446_at
6870
8102127
A_23_P110299
GE80636
GO:0003012
GO:0003013
GO:0004930
GO:0004995
GO:0005515
GO:0005886
GO:0005929
GO:0007018
GO:0007165
GO:0007186
GO:0007217
GO:0010460
GO:0016020
GO:0022414
GO:0023052
GO:0032355
GO:0032590
GO:0032809
GO:0042053
GO:0042220
GO:0043226
GO:0045777
GO:0048870
GO:0060089
GO:0060259
GO:0070474
GO:0097225
GO:1902093
HMNXSV003051885
ILMN_1658369
M89473_at
PH_hs_0000121
TC04001439.hg
TC04002656.hg
g7669547_3p_at
Participates
as an input of
Tachykinin receptor 3 (NK3) binds to neurokinin B (Homo sapiens)
as a member of
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
as a component of
TACR3:TAC3 [plasma membrane] (Homo sapiens)
Inferred To
tacr3 [plasma membrane]
(Xenopus tropicalis)
TACR3 [plasma membrane]
(Bos taurus)
TACR3 [plasma membrane]
(Canis familiaris)
TACR3 [plasma membrane]
(Gallus gallus)
TACR3 [plasma membrane]
(Sus scrofa)
Tacr3 [plasma membrane]
(Mus musculus)
Tacr3 [plasma membrane]
(Rattus norvegicus)
tkr-1 [plasma membrane]
(Caenorhabditis elegans)
tacr3l [plasma membrane]
(Danio rerio)
Cross References
RefSeq
NP_001050.1
ZINC - World Drugs
NK3R_HUMAN
Guide to Pharmacology - Targets
362
OpenTargets
ENSG00000169836
ZINC - FDA approved
NK3R_HUMAN
ZINC - Substances
NK3R_HUMAN
ZINC target
P29371
PRO
P29371
PDB
8JBF
ZINC - Investigational
NK3R_HUMAN
GeneCards
P29371
HPA
ENSG00000169836-TACR3
Ensembl
ENST00000304883
,
ENSG00000169836
,
ENSP00000303325
Pharos - Targets
P29371
Orphanet
18061
ZINC - Predictions - Purchasable
NK3R_HUMAN
HMDB Protein
HMDBP07844
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