Tachykinin receptor 3 (NK3) binds to neurokinin B

Stable Identifier
R-HSA-383373
Type
Reaction [binding]
Species
Homo sapiens
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Neurokinin B peptide (NKB) (Torricelli M et al, 2007) is a tachykinin-related neuropeptide that is highly expressed in the placenta.It can bind to its receptor, NK3 (Huang RR et al, 1992), which is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. Elevated levels of NKB in early pregnancy may be an indicator of hypertension and pre-eclampsia (Page NM et al, 2000), and treatment with certain neurokinin receptor antagonists may be useful in alleviating the symptoms.

Literature References
PubMed ID Title Journal Year
1374246 cDNA sequence and heterologous expression of the human neurokinin-3 receptor

Huang, RR, Cheung, AH, Mazina, KE, Strader, CD, Fong, TM

Biochem Biophys Res Commun 1992
10866201 Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia

Page, NM, Woods, RJ, Gardiner, SM, Lomthaisong, K, Gladwell, RT, Butlin, DJ, Manyonda, IT, Lowry, PJ

Nature 2000
17561251 Placental neurokinin B mRNA expression increases at preterm labor

Torricelli, M, Giovannelli, A, Leucci, E, Florio, P, De Falco, G, Torres, PB, Reis, FM, Leoncini, L, Petraglia, F

Placenta 2007
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