Reactome | ADCY6 [plasma membrane]

ADCY6 [plasma membrane]

Stable Identifier

R-HSA-379058

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Adenylate cyclase type 6, ADCY6_HUMAN

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Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to mechanical stimuli (Homo sapiens)
  - Response of endothelial cells to shear stress (Homo sapiens)
    - High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
      - Activated Adenylate cyclase catalyses cAMP synthesis (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY6 [plasma membrane] (Homo sapiens)
        
        G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY6 [plasma membrane] (Homo sapiens)
      - G alpha (s) activates adenylate cyclase (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY6 [plasma membrane] (Homo sapiens)
        
        G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY6 [plasma membrane] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Leishmania parasite growth and survival (Homo sapiens)
        
        Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
        
        Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
        
        G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY6 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY6 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (z):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY6 [plasma membrane] (Homo sapiens)
        
        G alpha (s) activates adenylate cyclase (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY6 [plasma membrane] (Homo sapiens)
        
        G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY6 [plasma membrane] (Homo sapiens)
        
        FCGR3A-mediated IL10 synthesis (Homo sapiens)
        
        Adenylate cyclase produces cAMP (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY6 [plasma membrane] (Homo sapiens)

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABA B receptor activation (Homo sapiens)
        
        Activation of GABAB receptors (Homo sapiens)
        
        Adenylate cyclase inhibitory pathway (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY6 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY6 [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY6 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY6 [plasma membrane] (Homo sapiens)
        
        Dissociation of the Gi alpha:G olf complex (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY6 [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY6 [plasma membrane] (Homo sapiens)
        
        G alpha (i) inhibits adenylate cyclase (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY6 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY6 [plasma membrane] (Homo sapiens)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY6 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY6 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43306 ADCY6

Gene Names

ADCY6, KIAA0422

Chain

chain:1-1168

Reference Genes

BioGPS Gene:112 ADCY6

COSMIC (genes):ADCY6 ADCY6

CTD Gene:112 ADCY6

dbSNP Gene:112 ADCY6

ENSEMBL:ENSG00000174233 ADCY6

HGNC:237 ADCY6

KEGG:hsa:112 ADCY6

Monarch:112 ADCY6

NCBI Gene:112 ADCY6

OMIM:600294 ADCY6

UCSC:O43306 ADCY6

Reference Transcript

Other Identifiers

112

11716725_a_at

11761681_a_at

16763984

209195_PM_s_at

209195_s_at

216743_PM_at

216743_at

3453249

3453251

3453253

3453254

3453255

3453256

3453257

3453258

3453260

3453261

3453262

3453263

3453264

3453265

3453266

3453267

3453268

3453269

3453270

3453271

3453272

3453273

3453274

3453275

3453276

3453277

3453278

3453279

3453280

3453281

3453282

3453283

3453284

3453285

3453286

3453287

3453288

3453289

3453290

3453291

3453292

3453293

3453294

3453295

3453296

3453297

3453299

3453300

3453301

3453303

3453310

39383_at

7962842

A_23_P501547

A_24_P929957

GE53174

GO:0000166

GO:0003013

GO:0003014

GO:0003091

GO:0003824

GO:0004016

GO:0005080

GO:0005515

GO:0005524

GO:0005886

GO:0005929

GO:0006171

GO:0007189

GO:0007191

GO:0007192

GO:0007193

GO:0007198

GO:0009190

GO:0009975

GO:0010977

GO:0016020

GO:0016829

GO:0016849

GO:0019901

GO:0032420

GO:0035556

GO:0035811

GO:0042995

GO:0043226

GO:0046872

GO:0055086

GO:0071380

GO:0071870

GO:0097746

GO:1901135

GO:1904117

GO:1904322

HMNXSV003051208

Hs.306727.0.A1_3p_at

ILMN_1685156

ILMN_2311674

PH_hs_0001172

TC12001457.hg

TC12002863.hg

g9049782_3p_a_at

Participates

as a candidate of

as a member of

Adenylate cyclase [plasma membrane] (Homo sapiens)

Inferred To

ACXA [plasma membrane] (Drosophila melanogaster)

Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)

CG12436 [plasma membrane] (Drosophila melanogaster)

adcy6 [plasma membrane] (Xenopus tropicalis)

ACXB [plasma membrane] (Drosophila melanogaster)

ADCY6 [plasma membrane] (Bos taurus)

ADCY6 [plasma membrane] (Canis familiaris)

ADCY6 [plasma membrane] (Gallus gallus)

ADCY6 [plasma membrane] (Sus scrofa)

acy-4 [plasma membrane] (Caenorhabditis elegans)

ACXE [plasma membrane] (Drosophila melanogaster)

ACXC [plasma membrane] (Drosophila melanogaster)

adcy6a [plasma membrane] (Danio rerio)

ACXD [plasma membrane] (Drosophila melanogaster)

CG8970 [plasma membrane] (Drosophila melanogaster)

Adcy6 [plasma membrane] (Mus musculus)

Adcy6 [plasma membrane] (Rattus norvegicus)

acaA [plasma membrane] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001377760.1, NP_001377759.1, XP_054226876.1, XP_047284129.1, NP_056085.1, XP_054226875.1, NP_001399748.1, NP_001399751.1, NP_001399750.1, NP_001399749.1, XP_006719273.1

Guide to Pharmacology - Targets

1283

OpenTargets

ENSG00000174233

ENSEMBL

ENSP00000311405, ENSP00000350536, ENSP00000446730, ENST00000307885, ENSG00000174233, ENST00000550422, ENST00000357869

HPA

ENSG00000174233-ADCY6

GeneCards

ADCY6

PRO

O43306

Pharos - Targets

O43306

Orphanet

ADCY6

GlyGen

O43306

HMDB Protein

HMDBP00706

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y4Z2 NEUROG3	1	NEUROG3 [nucleoplasm] (R-HSA-189530)	0.527	2

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