Reactome | CG12436 [plasma membrane]

CG12436 [plasma membrane]

Stable Identifier

R-DME-379058

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

plasma membrane

Synonyms

ADCY6, A8JNU1

Locations in the PathwayBrowser

Expand all

Neuronal System (Drosophila melanogaster)

- Transmission across Chemical Synapses (Drosophila melanogaster)
  - Neurotransmitter receptors and postsynaptic signal transmission (Drosophila melanogaster)
    - GABA receptor activation (Drosophila melanogaster)
      - GABA B receptor activation (Drosophila melanogaster)
        
        Activation of GABAB receptors (Drosophila melanogaster)
        
        Adenylate cyclase inhibitory pathway (Drosophila melanogaster)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Drosophila melanogaster)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Drosophila melanogaster)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Drosophila melanogaster)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Drosophila melanogaster)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Drosophila melanogaster)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
        
        Dissociation of the Gi alpha:G olf complex (Drosophila melanogaster)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Drosophila melanogaster)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Drosophila melanogaster)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Intracellular signaling by second messengers (Drosophila melanogaster)
  - DAG and IP3 signaling (Drosophila melanogaster)
    - CaM pathway (Drosophila melanogaster)
      - Calmodulin induced events (Drosophila melanogaster)
        
        PKA-mediated phosphorylation of CREB (Drosophila melanogaster)
        
        PKA activation (Drosophila melanogaster)
        
        Adenylate cyclase produces cAMP (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
- Signaling by GPCR (Drosophila melanogaster)
  - GPCR downstream signalling (Drosophila melanogaster)
    - G alpha (i) signalling events (Drosophila melanogaster)
      - Opioid Signalling (Drosophila melanogaster)
        
        G-protein mediated events (Drosophila melanogaster)
        
        Adenylate cyclase activating pathway (Drosophila melanogaster)
        
        Adenylate cyclase converts ATP into cyclic AMP (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
        
        Adenylaye cyclase increases the GTPase activity of G alpha-olf (Drosophila melanogaster)
        
        G alpha-olf:GDP:Adenylate cyclase (active) complex [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
        
        Galpha-olf:GTP binds to adenylate cyclase and activates it (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
        
        The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
        
        G alpha-olf:GDP:Adenylate cyclase (active) complex [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase inhibitory pathway (Drosophila melanogaster)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Drosophila melanogaster)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Drosophila melanogaster)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Drosophila melanogaster)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Drosophila melanogaster)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Drosophila melanogaster)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
        
        Dissociation of the Gi alpha:G olf complex (Drosophila melanogaster)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Drosophila melanogaster)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Drosophila melanogaster)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
        
        PLC beta mediated events (Drosophila melanogaster)
        
        Ca-dependent events (Drosophila melanogaster)
        
        CaM pathway (Drosophila melanogaster)
        
        Calmodulin induced events (Drosophila melanogaster)
        
        PKA-mediated phosphorylation of CREB (Drosophila melanogaster)
        
        PKA activation (Drosophila melanogaster)
        
        Adenylate cyclase produces cAMP (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
    - G alpha (z) signalling events (Drosophila melanogaster)
      - G alpha (z) inhibits adenylate cyclase (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
        
        G-protein alpha (z):GTP:Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)
- Signaling by Hedgehog (Drosophila melanogaster)
  - Hedgehog 'off' state (Drosophila melanogaster)
    - GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Drosophila melanogaster)
      - adenylate cyclases:Mg2+ [plasma membrane] (Drosophila melanogaster)
        
        adenylate cyclases [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)
        
        CG12436 [plasma membrane] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:A8JNU1

Gene Names

CG12436

Reference Genes

BioGPS Gene:39835 CG12436

ENSEMBL:FBgn0263131

FlyBase:FBgn0263131

KEGG:dme:Dmel_CG43373 CG12436

Monarch:39835 CG12436

NCBI Gene:39835 CG12436

UCSC:A8JNU1 CG12436

Reference Transcript

RefSeq:NM_001104152.4 CG12436

Other Identifiers

141806_at

148898_at

148899_at

1623703_at

1625043_at

1633015_at

1641693_s_at

39835

GO:0000166

GO:0003824

GO:0004016

GO:0005524

GO:0005886

GO:0006171

GO:0007189

GO:0007193

GO:0009190

GO:0009975

GO:0016020

GO:0016829

GO:0016849

GO:0035556

GO:0046872

GO:0055086

GO:1901135

Participates

as a member of

Homologues of ADCY6 [plasma membrane] (Drosophila melanogaster)

Other forms of this molecule

CG12436 [plasma membrane]

Inferred From

ADCY6 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001097622.2

FlyBase

FBgn0263131

Cite Us!