Glycogen synthase 1 (GYS1) catalyzes the incorporation of phosphoglucose into the glycogen-GYG1 molecules with which it is associated in a cytosolic glycogen granule. This reaction occurs at a low rate, yielding approximately one molecule of glucose phosphorylated at its C2, C3, or C6 positions incorporated into a growing glycogen polymer per ten thousand glucose molecules incorporated (DePaoli-Roach et al. 2015; Irimia et al. 2015; Nitschke et al. 2013; Tagliabracci et al. 2011). The function of these small amounts of phosphoglucose in normal glycogen remains to be established.
Ishihara, M, Segvich, DM, Heiss, C, Roach, PJ, Contreras, CJ, Azadi, P, DePaoli-Roach, AA
Zhao, X, Schmieder, P, Wang, P, Wang, T, Awrey, DE, Girard, JM, Heydenreich, M, Nitschke, F, Kleinpeter, E, Steup, M, Turnbull, J, Minassian, BA, Israelian, J
Ishihara, M, Hurley, TD, Glushka, J, Heiss, C, Karthik, C, Roach, PJ, Contreras, CJ, Tagliabracci, VS, DePaoli-Roach, AA, Azadi, P
Segvich, DM, Meyer, CM, Roach, PJ, Irimia, JM, Tagliabracci, VS, DePaoli-Roach, AA
glycogen synthase activity, transferring glucose-1-phosphate of PPP1R3C:glycogen-GYG1:GYS1-a tetramer [cytosol]
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