Glycogen synthase 1 (GYS1) catalyzes the incorporation of phosphoglucose into the glycogen-GYG1 molecules with which it is associated in a cytosolic glycogen granule. This reaction occurs at a low rate, yielding approximately one molecule of glucose phosphorylated at its C2, C3, or C6 positions incorporated into a growing glycogen polymer per ten thousand glucose molecules incorporated (DePaoli-Roach et al. 2015; Irimia et al. 2015; Nitschke et al. 2013; Tagliabracci et al. 2011). The function of these small amounts of phosphoglucose in normal glycogen remains to be established.
Segvich, DM, Meyer, CM, Roach, PJ, Irimia, JM, Tagliabracci, VS, DePaoli-Roach, AA
Ishihara, M, Segvich, DM, Heiss, C, Roach, PJ, Contreras, CJ, Azadi, P, DePaoli-Roach, AA
Zhao, X, Schmieder, P, Wang, P, Wang, T, Awrey, DE, Girard, JM, Heydenreich, M, Nitschke, F, Kleinpeter, E, Steup, M, Turnbull, J, Minassian, BA, Israelian, J
Ishihara, M, Hurley, TD, Glushka, J, Heiss, C, Karthik, C, Roach, PJ, Contreras, CJ, Tagliabracci, VS, DePaoli-Roach, AA, Azadi, P
glycogen synthase activity, transferring glucose-1-phosphate of PPP1R3C:glycogen-GYG1:GYS1-a tetramer [cytosol]
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