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XPO1 binds the beta-catenin:CBY complex
Stable Identifier
R-HSA-3769391
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Deactivation of the beta-catenin transactivating complex (Homo sapiens)
XPO1 binds the beta-catenin:CBY complex (Homo sapiens)
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CBY1 contains both NLS and NES sequences and continuously shuttles between the cytoplasm and the nucleus. Treatment of cells with leptomycin B (LMB), an inhibitor of XPO1-mediated nuclear export, results in nuclear accumulation of both CBY1 and 14-3-3/YWHAZ proteins (Li et al, 2008; Li et al, 2010). Consistent with this, CBY1 binds to XPO1 in an NES-dependent manner. 14-3-3/YWHAZ enhances the CBY1-XPO1 interaction, possibly by inducing a conformational change that exposes the adjacent NES sequence. Binding of 14-3-3/YWHAZ also inhibits the interaction of CBY1 with alpha-importin, additionally favouring its cytoplasmic localization. CBY1 NES mutants that are incapable of nuclear export show reduced ability to repress a beta-catenin-dependent reporter, and knockdown of endogenous CBY1 causes an accumulation of beta-catenin in the nucleus. These data support a role for CBY1 in the nuclear export of beta-catenin (Li et al, 2010). Despite growing evidence for a role for CBY1 in regulating WNT signaling, a formal requirement for CBY1 in vivo is still lacking.
Literature References
PubMed ID
Title
Journal
Year
19940019
Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin signaling
Hall, J
,
Mofunanya, A
,
Fischer, V
,
Takemaru, K
,
Li, FQ
Mol. Biol. Cell
2010
Participants
Input
XPO1 [nucleoplasm]
(Homo sapiens)
YWHAZ:p-S20-CBY:CTNNB1 [nucleoplasm]
(Homo sapiens)
Output
XPO1:YWHAZ:p-S20-CBY1:CTNNB1 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Deactivation of the beta-catenin transactivating complex (Homo sapiens)
Orthologous Events
XPO1 binds the beta-catenin:CBY complex (Bos taurus)
XPO1 binds the beta-catenin:CBY complex (Canis familiaris)
XPO1 binds the beta-catenin:CBY complex (Drosophila melanogaster)
XPO1 binds the beta-catenin:CBY complex (Gallus gallus)
XPO1 binds the beta-catenin:CBY complex (Mus musculus)
XPO1 binds the beta-catenin:CBY complex (Rattus norvegicus)
Authored
Rothfels, K (2013-05-30)
Reviewed
Rajakulendran, N (2014-01-22)
van Amerongen, R (2014-02-15)
Kikuchi, A (2014-04-22)
Created
Rothfels, K (2013-06-20)
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