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DKK2 [extracellular region]
Stable Identifier
R-HSA-3769326
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by WNT in cancer (Homo sapiens)
Signaling by LRP5 mutants (Homo sapiens)
misspliced mutants of LRP5 support enhanced beta-catenin-dependent signaling (Homo sapiens)
DKK [extracellular region] (Homo sapiens)
DKK2 [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Negative regulation of TCF-dependent signaling by WNT ligand antagonists (Homo sapiens)
DKK and KRM bind LRP5/6 (Homo sapiens)
DKK [extracellular region] (Homo sapiens)
DKK2 [extracellular region] (Homo sapiens)
KRM:DKK:LRP5/6 [plasma membrane] (Homo sapiens)
DKK [extracellular region] (Homo sapiens)
DKK2 [extracellular region] (Homo sapiens)
DKK promotes clathrin-dependent internalization of LRP6 (Homo sapiens)
KRM:DKK:LRP5/6 [plasma membrane] (Homo sapiens)
DKK [extracellular region] (Homo sapiens)
DKK2 [extracellular region] (Homo sapiens)
WNT binds to FZD and LRP5/6 (Homo sapiens)
KRM:DKK:LRP5/6 [plasma membrane] (Homo sapiens)
DKK [extracellular region] (Homo sapiens)
DKK2 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UBU2 DKK2
Gene Names
DKK2, UNQ682/PRO1316
Chain
signal peptide:1-33, chain:34-259
Reference Genes
BioGPS Gene:27123 DKK2
COSMIC (genes):DKK2 DKK2
CTD Gene:27123 DKK2
dbSNP Gene:27123 DKK2
ENSEMBL:ENSG00000155011 DKK2
HGNC:2892 DKK2
KEGG:hsa:27123 DKK2
Monarch:27123 DKK2
NCBI Gene:27123 DKK2
OMIM:605415 DKK2
UCSC:Q9UBU2 DKK2
Reference Transcript
RefSeq:NM_014421.2 DKK2
Other Identifiers
11728088_at
11728089_a_at
16978779
219908_PM_at
219908_at
224199_PM_at
224199_at
27123
2780908
2780909
2780910
2780911
2780912
2780913
2780931
2780932
2780933
2780939
2780956
2780957
49959_at
71137_at
8102200
A_23_P155848
A_24_P311679
GE62126
GO:0005515
GO:0005576
GO:0005615
GO:0007275
GO:0016055
GO:0030178
GO:0039706
GO:0048019
GO:0048856
GO:0090090
GO:0090263
GO:0098772
HMNXSV003001543
ILMN_1695506
ILMN_2194688
PH_hs_0040838
TC04001453.hg
g12249110_3p_a_at
g7657022_3p_at
Participates
as a candidate of
DKK [extracellular region] (Homo sapiens)
Other forms of this molecule
DKK2 [early endosome membrane]
Inferred To
Homologues of DKK2 [extracellular region]
(Dictyostelium discoideum)
DKK2 [extracellular region]
(Bos taurus)
DKK2 [extracellular region]
(Canis familiaris)
DKK2 [extracellular region]
(Dictyostelium discoideum)
DKK2 [extracellular region]
(Gallus gallus)
DKK2 [extracellular region]
(Sus scrofa)
Dkk2 [extracellular region]
(Mus musculus)
Dkk2 [extracellular region]
(Rattus norvegicus)
dkk2 [extracellular region]
(Danio rerio)
dkk2 [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_055236.1
ENSEMBL
ENST00000285311
,
ENSP00000285311
OpenTargets
ENSG00000155011
HPA
ENSG00000155011-DKK2
PRO
Q9UBU2
Pharos - Targets
Q9UBU2
GlyGen
Q9UBU2
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75581 LRP6
8
LRP6 [plasma membrane]
(R-HSA-206252)
p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-1458895)
p-2S,S1490,2T-LRP6 [plasma membrane]
(R-HSA-1458894)
LRP6N [extracellular region]
(R-HSA-5334021)
p-LRP6 [early endosome membrane]
(R-HSA-5368496)
LRP6 [early endosome membrane]
(R-HSA-5368481)
p-S1490-LRP6 [plasma membrane]
(R-HSA-206156)
p-T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-205884)
0.59
4
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