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INCENP [cytosol]
Stable Identifier
R-HSA-375311
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Mad1 binds kinetochore (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 recruits NUDC to mitotic spindle (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Kinetochore assembly (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA replication proteins (Homo sapiens)
RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Homo sapiens)
SUMO2,3:Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NQS7 INCENP
Gene Names
INCENP
Chain
chain:1-918
Reference Genes
BioGPS Gene:3619 INCENP
COSMIC (genes):INCENP INCENP
CTD Gene:3619 INCENP
dbSNP Gene:3619 INCENP
ENSEMBL:ENSG00000149503 INCENP
HGNC:6058 INCENP
KEGG:hsa:3619 INCENP
Monarch:3619 INCENP
NCBI Gene:3619 INCENP
OMIM:604411 INCENP
UCSC:Q9NQS7 INCENP
Reference Transcript
RefSeq:NM_020238.2 INCENP
RefSeq:NM_001040694.1 INCENP
Participates
as a component of
SUMO2,3:Chromosome passenger complex [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Other forms of this molecule
INCENP [nucleoplasm]
Inferred To
INCENP [cytosol]
(Bos taurus)
INCENP [cytosol]
(Canis familiaris)
INCENP [cytosol]
(Gallus gallus)
INCENP [cytosol]
(Sus scrofa)
incenp [cytosol]
(Xenopus tropicalis)
Incenp [cytosol]
(Drosophila melanogaster)
Incenp [cytosol]
(Mus musculus)
Incenp [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001035784.1
,
NP_064623.2
ENSEMBL
ENST00000394818
,
ENST00000278849
,
ENSP00000278849
,
ENSG00000149503
,
ENSP00000378295
OpenTargets
ENSG00000149503
GeneCards
INCENP
HPA
ENSG00000149503-INCENP
PRO
Q9NQS7
Pharos - Targets
Q9NQS7
GlyGen
Q9NQS7
PDB
6GR9
,
6GR8
,
5IEK
,
9ESA
,
6YIE
,
2QFA
,
4AF3
,
6YIF
,
5IEH
,
6YIH
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96GD4 AURKB
3
AURKB [cytosol]
(R-HSA-174231)
AURKB [nucleoplasm]
(R-HSA-4655360)
polySUMO2,3-K202-AURKB [cytosol]
(R-HSA-4655414)
0.962
22
UniProt:O15392 BIRC5
3
BIRC5 [cytosol]
(R-HSA-50851)
BIRC5 [nucleoplasm]
(R-HSA-4655344)
ub-BIRC5 [cytosol]
(R-HSA-8955933)
0.918
11
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.798
11
UniProt:O14965 AURKA
6
p-T288-AURKA [cytosol]
(R-HSA-2574832)
AURKA [cytosol]
(R-HSA-174254)
p-T288-AURKA [nucleoplasm]
(R-HSA-6805089)
PolyUb-AURKA [cytosol]
(R-HSA-8854040)
AURKA [nucleoplasm]
(R-HSA-4655443)
SUMO1-K258-AURKA [cytosol]
(R-HSA-4655367)
0.499
2
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