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SPC24 [cytosol]
Stable Identifier
R-HSA-375297
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
hSpc24
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
Mad1 binds kinetochore (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 recruits NUDC to mitotic spindle (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
Kinetochore assembly (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC24 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NBT2 SPC24
Gene Names
SPC24, SPBC24
Chain
chain:1-197
Reference Genes
BioGPS Gene:147841 SPC24
COSMIC (genes):SPC24 SPC24
CTD Gene:147841 SPC24
dbSNP Gene:147841 SPC24
ENSEMBL:ENSG00000161888 SPC24
HGNC:26913 SPC24
KEGG:hsa:147841 SPC24
Monarch:147841 SPC24
NCBI Gene:147841 SPC24
OMIM:609394 SPC24
UCSC:Q8NBT2 SPC24
Reference Transcript
RefSeq:NM_001317033.1 SPC24
RefSeq:XM_005259753.3 SPC24
RefSeq:NM_182513.3 SPC24
RefSeq:NM_001317031.1 SPC24
Other Identifiers
11735129_a_at
11751803_a_at
11751804_x_at
11759151_at
11762311_x_at
147841
16868838
217183_PM_at
235572_PM_at
235572_at
3850652
3850658
3850659
3850661
3850662
3850663
3850664
3850665
3850666
3850667
3850668
3850670
3850671
3850672
3850673
8034122
84183_at
A_24_P314571
A_33_P3376116
GE558258
GO:0000775
GO:0000776
GO:0000940
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005829
GO:0007059
GO:0007094
GO:0008017
GO:0008092
GO:0008608
GO:0031262
GO:0043226
GO:0051301
HMNXSV003009347
HMNXSV003022372
HMNXSV003057242
Hs.165190.0.A1_3p_at
Hs.213289.1.A1_3p_at
ILMN_2181432
PH_hs_0018590
TC19001177.hg
Participates
as a component of
NDC80 complex [cytosol] (Homo sapiens)
Inferred To
SPC24 [cytosol]
(Bos taurus)
SPC24 [cytosol]
(Canis familiaris)
SPC24 [cytosol]
(Sus scrofa)
spc24 [cytosol]
(Xenopus tropicalis)
Ghost homologue of SPC24 [cytosol]
(Gallus gallus)
Spc24 [cytosol]
(Mus musculus)
Spc24 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001303960.1
,
NP_872319.1
,
XP_005259810.1
,
NP_001303962.1
ENSEMBL
ENSG00000161888
,
ENSP00000465075
,
ENST00000592540
OpenTargets
ENSG00000161888
GeneCards
SPC24
HPA
ENSG00000161888-SPC24
PRO
Q8NBT2
Pharos - Targets
Q8NBT2
PDB
8PPR
,
8Q5H
,
3IZ0
,
2VE7
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96ES7 SGF29
1
SGF29 [nucleoplasm]
(R-HSA-3662279)
0.527
3
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