Reactome | SSTR1 [plasma membrane]

SSTR1 [plasma membrane]

Stable Identifier

R-HSA-374741

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Somatostatin receptor type 1, SSR1_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR1 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR1 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR1 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Somatostatin receptors bind somatostatin and cortistatin (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR1 [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P30872 SSTR1

Gene Names

SSTR1

Chain

chain:1-391

Reference Genes

BioGPS Gene:6751 SSTR1

COSMIC (genes):SSTR1 SSTR1

CTD Gene:6751 SSTR1

dbSNP Gene:6751 SSTR1

ENSEMBL:ENSG00000139874 SSTR1

ENSEMBL_homo_sapiens_GENE:ENSG00000139874.6 SSTR1

HGNC:11330 SSTR1

KEGG Gene (Homo sapiens):6751 SSTR1

Monarch:6751 SSTR1

NCBI Gene:6751 SSTR1

OMIM:182451 SSTR1

UCSC:P30872 SSTR1

Reference Transcript

RefSeq:NM_001049.2 SSTR1

Other Identifiers

11728041_at

11753443_a_at

16783602

208482_PM_at

208482_at

235591_PM_at

235591_at

3533190

3533191

3533193

3533194

3533195

3533196

3533197

6751

73968_at

7974047

84092_at

A_14_P132679

A_14_P201377

A_24_P244706

GE80008

GO:0004930

GO:0004994

GO:0005515

GO:0005886

GO:0007165

GO:0007186

GO:0007187

GO:0007215

GO:0007218

GO:0007283

GO:0008285

GO:0016020

GO:0021549

GO:0022414

GO:0023052

GO:0030900

GO:0038170

GO:0042594

GO:0042923

GO:0043005

GO:0048856

GO:0060089

GO:0071392

GO:1990830

HMNXSV003051733

Hs.126059.0.A1_3p_at

ILMN_1673998

ILMN_2069745

M81829_at

PH_hs_0028024

PH_hs_0030708

TC14000243.hg

g4557856_3p_at

Participates

as a member of

Somatostatin receptors [plasma membrane] (Homo sapiens)

Inferred To

SS1R [plasma membrane] (Gallus gallus)

SSTR1 [plasma membrane] (Bos taurus)

SSTR1 [plasma membrane] (Canis familiaris)

SSTR1 [plasma membrane] (Sus scrofa)

Sstr1 [plasma membrane] (Mus musculus)

Sstr1 [plasma membrane] (Rattus norvegicus)

sstr1 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001040.1

Guide to Pharmacology - Targets

355

OpenTargets

ENSG00000139874

GeneCards

P30872

ZINC - Substances

SSR1_HUMAN

HPA

ENSG00000139874-SSTR1

Ensembl

ENSG00000139874, ENSP00000267377, ENST00000267377

ZINC target

P30872

PRO

P30872

Pharos - Targets

P30872

ZINC - Predictions - Purchasable

SSR1_HUMAN