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PENK(210-214) [extracellular region]
Stable Identifier
R-HSA-374379
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Met-enkephalin (210-214), PENK_HUMAN, PENK
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Opioid receptor:opioid ligand [plasma membrane] (Homo sapiens)
Opioid ligands [extracellular region] (Homo sapiens)
PENK(210-214) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Opioid receptor:opioid ligand [plasma membrane] (Homo sapiens)
Opioid ligands [extracellular region] (Homo sapiens)
PENK(210-214) [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Opioid receptor:opioid ligand [plasma membrane] (Homo sapiens)
Opioid ligands [extracellular region] (Homo sapiens)
PENK(210-214) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Opioid receptor:opioid ligand [plasma membrane] (Homo sapiens)
Opioid ligands [extracellular region] (Homo sapiens)
PENK(210-214) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Opioid receptor:opioid ligand [plasma membrane] (Homo sapiens)
Opioid ligands [extracellular region] (Homo sapiens)
PENK(210-214) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Opioid receptor:opioid ligand [plasma membrane] (Homo sapiens)
Opioid ligands [extracellular region] (Homo sapiens)
PENK(210-214) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Opioid receptors bind opioid peptides (Homo sapiens)
Opioid ligands [extracellular region] (Homo sapiens)
PENK(210-214) [extracellular region] (Homo sapiens)
Opioid receptor:opioid ligand [plasma membrane] (Homo sapiens)
Opioid ligands [extracellular region] (Homo sapiens)
PENK(210-214) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01210 PENK
Gene Names
PENK
Chain
signal peptide:1-24, peptide:25-97, peptide:100-104, peptide:107-111, peptide:114-133, peptide:136-140, peptide:143-183, peptide:186-193, propeptide:196-207, peptide:210-214, propeptide:217-227, peptide:230-234, peptide:237-258, peptide:261-267
Reference Genes
BioGPS Gene:5179 PENK
COSMIC (genes):PENK PENK
CTD Gene:5179 PENK
dbSNP Gene:5179 PENK
ENSEMBL:ENSG00000181195 PENK
ENSEMBL_homo_sapiens_GENE:ENSG00000181195.11 PENK
HGNC:8831 PENK
KEGG Gene (Homo sapiens):5179 PENK
Monarch:5179 PENK
NCBI Gene:5179 PENK
OMIM:131330 PENK
UCSC:P01210 PENK
Reference Transcript
RefSeq:NM_001135690.2 PENK
Other Identifiers
11720425_a_at
213791_PM_at
213791_at
3136273
3136274
3136279
3136280
3136281
3136284
3136286
38291_at
5179
8150901
A_23_P417918
GE59611
GO:0001515
GO:0001649
GO:0001662
GO:0001666
GO:0001964
GO:0002118
GO:0005184
GO:0005576
GO:0005783
GO:0005788
GO:0005886
GO:0007165
GO:0007218
GO:0007268
GO:0007600
GO:0007626
GO:0009617
GO:0009636
GO:0014009
GO:0019226
GO:0019233
GO:0023052
GO:0030154
GO:0030424
GO:0030425
GO:0031410
GO:0031628
GO:0032280
GO:0032355
GO:0032496
GO:0034466
GO:0034592
GO:0034599
GO:0035094
GO:0035641
GO:0038003
GO:0043025
GO:0043204
GO:0043226
GO:0043679
GO:0045471
GO:0048018
GO:0048856
GO:0050877
GO:0051592
GO:0051867
GO:0070852
GO:0071305
GO:0071320
GO:0071560
GO:0071871
GO:0098586
GO:0098772
GO:0099013
GO:0099538
GO:2000987
HMNXSV003039784
Hs.93557.0.S1_3p_at
ILMN_1726711
J00123_at
PH_hs_0023886
Participates
as a member of
Opioid ligands [extracellular region] (Homo sapiens)
Other forms of this molecule
p-PENK [endoplasmic reticulum lumen]
PENK [endoplasmic reticulum lumen]
PENK(136-140) [extracellular region]
PENK(230-234) [extracellular region]
PENK(100-104) [extracellular region]
PENK(107-111) [extracellular region]
Inferred To
penk [extracellular region]
(Danio rerio)
penk [extracellular region]
(Xenopus tropicalis)
Penk [extracellular region]
(Mus musculus)
Penk [extracellular region]
(Rattus norvegicus)
PENK(210-214) [extracellular region]
(Sus scrofa)
PENK [extracellular region]
(Bos taurus)
PENK [extracellular region]
(Canis familiaris)
PENK [extracellular region]
(Gallus gallus)
Cross References
RefSeq
NP_001129162.1
OpenTargets
ENSG00000181195
GeneCards
P01210
HPA
ENSG00000181195-PENK
Ensembl
ENST00000451791
,
ENSP00000400894
,
ENSP00000324248
,
ENSG00000181195
,
ENST00000314922
PRO
P01210
Pharos - Targets
P01210
PDB
5E33
,
1PLW
,
2LWC
,
5E3A
,
1PLX
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