Reactome | BDKRB1 [plasma membrane]

BDKRB1 [plasma membrane]

Stable Identifier

R-HSA-374257

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

B1 bradykinin receptor, BKRB1_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB1 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB1 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB1 [plasma membrane] (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB1 [plasma membrane] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB1 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB1 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Bradykinin receptors B1 and B2 bind to bradykinin (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB1 [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P46663 BDKRB1

Gene Names

BDKRB1, BRADYB1

Chain

chain:1-353

Reference Genes

BioGPS Gene:623 BDKRB1

COSMIC - genes:BDKRB1 BDKRB1

CTD Gene:623 BDKRB1

dbSNP Gene:623 BDKRB1

ENSEMBL:ENSG00000100739 BDKRB1

HGNC:1029 BDKRB1

KEGG:hsa:623 BDKRB1

Monarch:623 BDKRB1

NCBI Gene:623 BDKRB1

OMIM:600337 BDKRB1

UCSC:P46663 BDKRB1

Reference Transcript

Other Identifiers

11728504_a_at

16788036

207510_PM_at

207510_at

3550309

3550310

3550312

3550313

3550314

3550315

3550317

623

7976567

A_14_P125188

A_23_P128744

A_24_P919850

GE80939

GO:0002687

GO:0004930

GO:0004947

GO:0005515

GO:0005783

GO:0005886

GO:0006954

GO:0007165

GO:0007186

GO:0007204

GO:0009612

GO:0016020

GO:0016477

GO:0030308

GO:0032496

GO:0042277

GO:0045776

GO:0048870

GO:0051281

HMNXSV003029939

ILMN_1734611

PH_hs_0003282

TC14001832.hg

TC14002311.hg

g4502390_3p_at

Participates

as a member of

Bradykinin receptor [plasma membrane] (Homo sapiens)

Inferred To

Homologues of BDKRB1 [plasma membrane] (Caenorhabditis elegans)

npr-15 [plasma membrane] (Caenorhabditis elegans)

Bdkrb1 [plasma membrane] (Mus musculus)

Bdkrb1 [plasma membrane] (Rattus norvegicus)

npr-33 [plasma membrane] (Caenorhabditis elegans)

npr-31 [plasma membrane] (Caenorhabditis elegans)

BDKRB1 [plasma membrane] (Canis familiaris)

BDKRB1 [plasma membrane] (Gallus gallus)

BDKRB2 [plasma membrane] (Bos taurus)

Cross References

RefSeq

NP_001372936.1, NP_000701.2

Guide to Pharmacology - Targets

ENSEMBL

ENST00000216629, ENST00000611804, ENSP00000479276, ENSG00000100739, ENSP00000216629

OpenTargets

ENSG00000100739

ZINC - Substances

BKRB1_HUMAN

ZINC target

P46663

PRO

P46663

GlyGen

P46663

PDB

7EIB

ZINC - Investigational

BKRB1_HUMAN

GeneCards

BDKRB1

HPA

ENSG00000100739-BDKRB1

Pharos - Targets

P46663

ZINC - Predictions - Purchasable

BKRB1_HUMAN

HMDB Protein

HMDBP10813

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