G protein-coupled estrogen receptor 1 binds estrogen non-classically

Stable Identifier
R-HSA-374207
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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G protein-coupled estrogen receptor 1 (GPER; CEPR; G-protein coupled receptor 30, GPR30) (Feng Y and Gregor P, 1997) has a ubiquitous tissue distribution. This orphan receptor is unrelated to nuclear estrogen receptors, but shows all the binding and signaling characteristics of a membrane estrogen receptor (mER). This suggests a role for GPCRs in nonclassical steroid hormone actions.

Literature References
PubMed ID Title Journal Year
15539556 Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells

Thomas, P, Pang, Y, Filardo, E J, Dong, J

Endocrinology 2005
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