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GPER1 [plasma membrane]
Stable Identifier
R-HSA-374191
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
G-protein coupled estrogen receptor 1, GPER_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GPER1:ESTG [plasma membrane] (Homo sapiens)
GPER1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GPER1:ESTG [plasma membrane] (Homo sapiens)
GPER1 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GPER1:ESTG [plasma membrane] (Homo sapiens)
GPER1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GPER1:ESTG [plasma membrane] (Homo sapiens)
GPER1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GPER1:ESTG [plasma membrane] (Homo sapiens)
GPER1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GPER1:ESTG [plasma membrane] (Homo sapiens)
GPER1 [plasma membrane] (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
GPER1 signaling (Homo sapiens)
ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Homo sapiens)
GPER1:Heterotrimeric G-protein Gs (active):ESTG [plasma membrane] (Homo sapiens)
GPER1 [plasma membrane] (Homo sapiens)
GPER1:Heterotrimeric G-protein Gs:ESTG [plasma membrane] (Homo sapiens)
GPER1:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
GPER1 [plasma membrane] (Homo sapiens)
ESTG-stimulated dissociation of GPER:heterotrimeric G-protein (s) complex (Homo sapiens)
GPER1:ESTG [plasma membrane] (Homo sapiens)
GPER1 [plasma membrane] (Homo sapiens)
GPER1:Heterotrimeric G-protein Gs (active):ESTG [plasma membrane] (Homo sapiens)
GPER1 [plasma membrane] (Homo sapiens)
GPER:Heterotrimeric G-protein Gs binds ESTG (Homo sapiens)
GPER1:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
GPER1 [plasma membrane] (Homo sapiens)
GPER1:Heterotrimeric G-protein Gs:ESTG [plasma membrane] (Homo sapiens)
GPER1:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
GPER1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
G protein-coupled estrogen receptor 1 binds estrogen non-classically (Homo sapiens)
GPER1 [plasma membrane] (Homo sapiens)
GPER1:ESTG [plasma membrane] (Homo sapiens)
GPER1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99527 GPER1
Gene Names
GPER1, CEPR, CMKRL2, DRY12, GPER, GPR30
Chain
chain:1-375
Reference Genes
BioGPS Gene:2852 GPER1
COSMIC (genes):GPER1 GPER1
CTD Gene:2852 GPER1
dbSNP Gene:2852 GPER1
ENSEMBL:ENSG00000164850 GPER1
HGNC:4485 GPER1
KEGG:hsa:2852 GPER1
Monarch:2852 GPER1
NCBI Gene:2852 GPER1
OMIM:601805 GPER1
UCSC:Q99527 GPER1
Reference Transcript
RefSeq:NM_001098201.1 GPER1
RefSeq:NM_001505.2 GPER1
RefSeq:NM_001039966.1 GPER1
Other Identifiers
11728064_a_at
11732410_a_at
11732411_x_at
11732412_a_at
11750246_a_at
11750247_x_at
11753236_a_at
11753608_a_at
11753609_x_at
17042857
17042860
210640_PM_s_at
210640_s_at
211829_PM_s_at
211829_s_at
2852
2987037
2987040
2987041
2987042
2987043
2987044
2987048
2987049
2987050
2987051
2987052
2987053
2987054
2987055
2987056
2987057
2987058
2987059
2987060
2987061
2987062
37447_at
8131069
A_23_P8640
A_33_P3345812
A_33_P3345816
A_33_P3356752
GE80129
GO:0000139
GO:0001934
GO:0001956
GO:0002376
GO:0002695
GO:0003013
GO:0003682
GO:0004930
GO:0005496
GO:0005515
GO:0005634
GO:0005635
GO:0005654
GO:0005730
GO:0005737
GO:0005739
GO:0005768
GO:0005769
GO:0005783
GO:0005789
GO:0005794
GO:0005802
GO:0005829
GO:0005856
GO:0005886
GO:0006355
GO:0006915
GO:0006954
GO:0007186
GO:0007189
GO:0007204
GO:0007399
GO:0008284
GO:0008285
GO:0008289
GO:0010628
GO:0010629
GO:0010948
GO:0012501
GO:0014069
GO:0016020
GO:0019228
GO:0030154
GO:0030263
GO:0030264
GO:0030284
GO:0030335
GO:0030424
GO:0030425
GO:0030518
GO:0030659
GO:0031410
GO:0031966
GO:0032024
GO:0032591
GO:0032962
GO:0038054
GO:0042311
GO:0042734
GO:0042995
GO:0043065
GO:0043198
GO:0043226
GO:0043231
GO:0043280
GO:0043401
GO:0043410
GO:0043679
GO:0044327
GO:0045087
GO:0045095
GO:0045202
GO:0045599
GO:0045742
GO:0045745
GO:0045944
GO:0048471
GO:0048786
GO:0048856
GO:0050728
GO:0050769
GO:0050804
GO:0051055
GO:0051281
GO:0051480
GO:0051726
GO:0051897
GO:0051898
GO:0055037
GO:0060089
GO:0061024
GO:0070373
GO:0070374
GO:0070474
GO:0071333
GO:0071356
GO:0071375
GO:0071389
GO:0071392
GO:0090200
GO:0098542
GO:0098686
GO:0140110
GO:1903078
GO:1904706
GO:1990239
GO:2000353
GO:2000724
GO:2001238
HMNXSV003050121
HMNXSV003057082
ILMN_1665435
ILMN_1795298
ILMN_2384056
PH_hs_0006232
TC07000018.hg
U77827_at
g1381668_3p_a_at
g2656120_3p_a_at
p15198
Participates
as a component of
GPER1:Heterotrimeric G-protein Gs (active):ESTG [plasma membrane] (Homo sapiens)
GPER1:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
GPER1:ESTG [plasma membrane] (Homo sapiens)
as an input of
G protein-coupled estrogen receptor 1 binds estrogen non-classically (Homo sapiens)
Inferred To
GPER1 [plasma membrane]
(Canis familiaris)
GPER1 [plasma membrane]
(Gallus gallus)
GPER1 [plasma membrane]
(Sus scrofa)
Gper1 [plasma membrane]
(Mus musculus)
Gper1 [plasma membrane]
(Rattus norvegicus)
gper1 [plasma membrane]
(Danio rerio)
gper1 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001496.1
,
NP_001035055.1
,
NP_001091671.1
Guide to Pharmacology - Targets
221
ENSEMBL
ENSG00000164850
,
ENST00000401670
,
ENST00000397088
,
ENSP00000297469
,
ENSP00000380281
,
ENST00000297469
,
ENSP00000385151
,
ENSP00000380277
,
ENST00000397092
OpenTargets
ENSG00000164850
ZINC - FDA approved
GPER1_HUMAN
ZINC - Substances
GPER1_HUMAN
ZINC - Biogenic
GPER1_HUMAN
ZINC target
Q99527
PRO
Q99527
GlyGen
Q99527
PDB
8XOH
,
8XOF
,
8XOJ
,
8XOG
,
8XOI
ZINC - Metabolites
GPER1_HUMAN
GeneCards
GPER1
HPA
ENSG00000164850-GPER1
Pharos - Targets
Q99527
HMDB Protein
HMDBP12793
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