BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region

Stable Identifier
R-HSA-373875
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
lactate + H+ [cytosol] <=> lactate + H+ [extracellular]
Locations in the PathwayBrowser
General
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The membrane-associated MCT:basigin complex mediates the reversible export of cytosolic lactate and H+ (Wilson et al. 2005).

Literature References
PubMed ID Title Journal Year
15917240 Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)

Wilson, MC, Meredith, D, Fox, JE, Manoharan, C, Davies, AJ, Halestrap, AP

J Biol Chem 2005
Participants
Participates
Catalyst Activity

lactate transmembrane transporter activity of BSG:MCTs [plasma membrane]

Orthologous Events
Cross References
Rhea
Authored
Created
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