BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region

Stable Identifier
R-HSA-373875
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane, extracellular region
Synonyms
lactate + H+ [cytosol] <=> lactate + H+ [extracellular]
ReviewStatus
5/5
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BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region
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The membrane-associated MCT:basigin complex mediates the reversible export of cytosolic lactate and H+ (Wilson et al. 2005).
Literature References
PubMed ID Title Journal Year
15917240 Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)

Meredith, D, Davies, AJ, Halestrap, AP, Fox, JE, Wilson, MC, Manoharan, C

J Biol Chem 2005
Participants
Input
Output
Participates
as an event of
Catalyst Activity

lactate transmembrane transporter activity of BSG:MCTs [plasma membrane]

Physical Entity
BSG:MCTs [plasma membrane] (Homo sapiens)
Activity
lactate transmembrane transporter activity (GO:0015129)
Orthologous Events
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Bos taurus)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Caenorhabditis elegans)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Canis familiaris)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Drosophila melanogaster)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Gallus gallus)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Mus musculus)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Rattus norvegicus)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Sus scrofa)
BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Xenopus tropicalis)
lactate + H+ [cytosol] <=> lactate + H+ [extracellular] (Gallus gallus)
Cross References
RHEA
Rhea
Authored
D'Eustachio, P  (2008-07-17)
Created
D'Eustachio, P  (2008-07-17)
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