BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol

Stable Identifier
R-HSA-373867
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane, extracellular region
Synonyms
lactate + H+ [extracellular] <=> lactate + H+ [cytosol]
ReviewStatus
5/5
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BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol
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The membrane-associated MCT:basigin complex mediates the reversible uptake of extracellular lactate and H+ (Wilson et al. 2005).
Literature References
PubMed ID Title Journal Year
15917240 Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)

Wilson, MC, Meredith, D, Fox, JE, Manoharan, C, Davies, AJ, Halestrap, AP

J Biol Chem 2005
Participants
Input
Output
Participates
as an event of
Catalyst Activity

lactate transmembrane transporter activity of BSG:MCTs [plasma membrane]

Physical Entity
BSG:MCTs [plasma membrane] (Homo sapiens)
Activity
lactate transmembrane transporter activity (GO:0015129)
Orthologous Events
lactate + H+ [extracellular] <=> lactate + H+ [cytosol] (Gallus gallus)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Caenorhabditis elegans)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Danio rerio)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Drosophila melanogaster)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Gallus gallus)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Mus musculus)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Rattus norvegicus)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Xenopus tropicalis)
Cross References
RHEA
Authored
D'Eustachio, P  (2008-07-17)
Created
D'Eustachio, P  (2008-07-17)
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