Receptor CXCR1 binds CXCL6 and CXCL8 ligands

Stable Identifier
R-HSA-373791
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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CXCR1 (high affinity interleukin-8 receptor A) (Holmes WE et al, 1991) is closely related to CXCR2. They recognize CXC chemokines that possess an E-L-R amino acid motif immediately adjacent to their CXC motif. CXCL8 (interleukin-8, IL-8) (Matsushima K et al, 1988) and CXCL6 (Rovai LE et al, 1997) can both bind CXCR1 in humans and elicit various effects. CXCL8 attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. CXCL6 is a chemotactic factor for neutrophil granulocytes.

Literature References
PubMed ID Title Journal Year
9164944 Cloning and characterization of the human granulocyte chemotactic protein-2 gene

Rovai, LE, Herschman, HR, Smith, JB

J Immunol 1997
3260265 Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor

Matsushima, K, Morishita, K, Yoshimura, T, Lavu, S, Kobayashi, Y, Lew, W, Appella, E, Kung, HF, Leonard, EJ, Oppenheim, JJ

J Exp Med 1988
1840701 Structure and functional expression of a human interleukin-8 receptor

Holmes, WE, Lee, J, Kuang, WJ, Rice, GC, Wood, WI

Science 1991
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