Receptor CXCR1 binds CXCL6 and CXCL8 ligands

Stable Identifier
R-HSA-373791
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CXCR1 (high affinity interleukin-8 receptor A) (Holmes WE et al, 1991) is closely related to CXCR2. They recognize CXC chemokines that possess an E-L-R amino acid motif immediately adjacent to their CXC motif. CXCL8 (interleukin-8, IL-8) (Matsushima K et al, 1988) and CXCL6 (Rovai LE et al, 1997) can both bind CXCR1 in humans and elicit various effects. CXCL8 attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. CXCL6 is a chemotactic factor for neutrophil granulocytes.

Literature References
PubMed ID Title Journal Year
3260265 Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor

Kobayashi, Y, Lavu, S, Yoshimura, T, Oppenheim, JJ, Kung, HF, Lew, W, Appella, E, Morishita, K, Leonard, EJ, Matsushima, K

J Exp Med 1988
9164944 Cloning and characterization of the human granulocyte chemotactic protein-2 gene

Rovai, LE, Smith, JB, Herschman, HR

J Immunol 1997
1840701 Structure and functional expression of a human interleukin-8 receptor

Kuang, WJ, Holmes, WE, Lee, J, Wood, WI, Rice, GC

Science 1991
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!