Receptor CXCR1 binds CXCL6 and CXCL8 ligands

Stable Identifier
Reaction [binding]
Homo sapiens
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CXCR1 (high affinity interleukin-8 receptor A) (Holmes WE et al, 1991) is closely related to CXCR2. They recognize CXC chemokines that possess an E-L-R amino acid motif immediately adjacent to their CXC motif. CXCL8 (interleukin-8, IL-8) (Matsushima K et al, 1988) and CXCL6 (Rovai LE et al, 1997) can both bind CXCR1 in humans and elicit various effects. CXCL8 attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. CXCL6 is a chemotactic factor for neutrophil granulocytes.
Literature References
PubMed ID Title Journal Year
3260265 Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor

Kobayashi, Y, Lavu, S, Yoshimura, T, Oppenheim, JJ, Kung, HF, Lew, W, Appella, E, Morishita, K, Leonard, EJ, Matsushima, K

J Exp Med 1988
9164944 Cloning and characterization of the human granulocyte chemotactic protein-2 gene

Rovai, LE, Smith, JB, Herschman, HR

J Immunol 1997
1840701 Structure and functional expression of a human interleukin-8 receptor

Kuang, WJ, Holmes, WE, Lee, J, Wood, WI, Rice, GC

Science 1991
Orthologous Events
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