CXCR1 (high affinity interleukin-8 receptor A) (Holmes WE et al, 1991) is closely related to CXCR2. They recognize CXC chemokines that possess an E-L-R amino acid motif immediately adjacent to their CXC motif. CXCL8 (interleukin-8, IL-8) (Matsushima K et al, 1988) and CXCL6 (Rovai LE et al, 1997) can both bind CXCR1 in humans and elicit various effects. CXCL8 attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. CXCL6 is a chemotactic factor for neutrophil granulocytes.
Rovai, LE, Herschman, HR, Smith, JB
Matsushima, K, Morishita, K, Yoshimura, T, Lavu, S, Kobayashi, Y, Lew, W, Appella, E, Kung, HF, Leonard, EJ, Oppenheim, JJ
Holmes, WE, Lee, J, Kuang, WJ, Rice, GC, Wood, WI
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