Reactome | Receptor CXCR1 binds CXCL6 and CXCL8 ligands

Receptor CXCR1 binds CXCL6 and CXCL8 ligands

Stable Identifier

R-HSA-373791

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Homo sapiens)

General

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Receptor CXCR1 binds CXCL6 and CXCL8 ligands

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CXCR1 (high affinity interleukin-8 receptor A) (Holmes WE et al, 1991) is closely related to CXCR2. They recognize CXC chemokines that possess an E-L-R amino acid motif immediately adjacent to their CXC motif. CXCL8 (interleukin-8, IL-8) (Matsushima K et al, 1988) and CXCL6 (Rovai LE et al, 1997) can both bind CXCR1 in humans and elicit various effects. CXCL8 attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. CXCL6 is a chemotactic factor for neutrophil granulocytes.

Literature References

PubMed ID	Title	Journal	Year
9164944	Cloning and characterization of the human granulocyte chemotactic protein-2 gene Rovai, LE, Herschman, HR, Smith, JB	J Immunol	1997
3260265	Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor Matsushima, K, Morishita, K, Yoshimura, T, Lavu, S, Kobayashi, Y, Lew, W, Appella, E, Kung, HF, Leonard, EJ, Oppenheim, JJ	J Exp Med	1988
1840701	Structure and functional expression of a human interleukin-8 receptor Holmes, WE, Lee, J, Kuang, WJ, Rice, GC, Wood, WI	Science	1991