Reactome | CXCL1(35-107) [extracellular region]

CXCL1(35-107) [extracellular region]

Stable Identifier

R-HSA-373778

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

CXCL1, Growth-regulated alpha protein precursor, GROA_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL1(35-107) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL1(35-107) [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL1(35-107) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL1(35-107) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL1(35-107) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL1(35-107) [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptor CXCR2 binds ligands CXCL1 to 7 (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL1(35-107) [extracellular region] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL1(35-107) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P09341 CXCL1

Gene Names

CXCL1, GRO, GRO1, GROA, MGSA, SCYB1

Chain

signal peptide:1-34, chain:35-107, chain:38-107, chain:39-107, chain:40-107

Reference Genes

BioGPS Gene:2919 CXCL1

COSMIC (genes):CXCL1 CXCL1

CTD Gene:2919 CXCL1

dbSNP Gene:2919 CXCL1

ENSEMBL:ENSG00000163739 CXCL1

ENSEMBL_homo_sapiens_GENE:ENSG00000163739.5 CXCL1

HGNC:4602 CXCL1

KEGG Gene (Homo sapiens):2919 CXCL1

Monarch:2919 CXCL1

NCBI Gene:2919 CXCL1

OMIM:155730 CXCL1

UCSC:P09341 CXCL1

Reference Transcript

RefSeq:NM_001511.3 CXCL1

Other Identifiers

11719366_s_at

11754114_a_at

11763250_x_at

204470_PM_at

204470_at

2731382

2731383

2731385

2731387

2731388

2731389

2731390

2773395

2773396

2773445

2919

408_at

8095697

A_23_P7144

A_33_P3330264

GO:0002376

GO:0005102

GO:0005125

GO:0005515

GO:0005576

GO:0005615

GO:0006935

GO:0006952

GO:0006954

GO:0006955

GO:0007010

GO:0007165

GO:0007186

GO:0007399

GO:0008009

GO:0008047

GO:0008083

GO:0008285

GO:0023052

GO:0030036

GO:0030593

GO:0031410

GO:0035556

GO:0035580

GO:0043226

GO:0045236

GO:0048018

GO:0048856

GO:0048870

GO:0061844

GO:0070098

GO:0071222

GO:0098542

GO:0098772

GO:1904724

HMNXSV003004178

HMNXSV003030638

ILMN_1787897

PH_hs_0028689

PH_hs_0030857

TC04000411.hg

X54489_rna1_at

g4504152_3p_at

Participates

as a member of

Other forms of this molecule

CXCL1(35-107) [specific granule lumen]

CXCL1(35-107) [tertiary granule lumen]

Inferred To

LOC100525396 [extracellular region] (Sus scrofa)

Homologues of CXCL1(35-107) [extracellular region] (Danio rerio)

Homologues of CXCL1(35-107) [extracellular region] (Gallus gallus)

cxcl8b.1 [extracellular region] (Danio rerio)

k60 [extracellular region] (Gallus gallus)

CXCL8 [extracellular region] (Gallus gallus)

Cxcl1 [extracellular region] (Mus musculus)

Cxcl1 [extracellular region] (Rattus norvegicus)

cxcl8b.3 [extracellular region] (Danio rerio)

CXCL1(35-107) [extracellular region] (Bos taurus)

CXCL1(35-107) [extracellular region] (Gallus gallus)

Cross References

RefSeq

NP_001502.1

OpenTargets

ENSG00000163739

GeneCards

P09341

HPA

ENSG00000163739-CXCL1

Ensembl

ENSG00000163739, ENST00000395761, ENSP00000379110

PRO

P09341

Pharos - Targets

P09341

PDB

1MSH, 1MGS, 1ROD, 1MSG