Reactome | CXCL3(35-107) [extracellular region]

CXCL3(35-107) [extracellular region]

Stable Identifier

R-HSA-373774

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

CXCL3, Macrophage inflammatory protein 2-beta, MIP2B_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL3(35-107) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL3(35-107) [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL3(35-107) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL3(35-107) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL3(35-107) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL3(35-107) [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptor CXCR2 binds ligands CXCL1 to 7 (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL3(35-107) [extracellular region] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL3(35-107) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P19876 CXCL3

Gene Names

CXCL3, GRO3, GROG, SCYB3

Chain

signal peptide:1-34, chain:35-107, chain:39-107

Reference Genes

BioGPS Gene:2921 CXCL3

COSMIC (genes):CXCL3 CXCL3

CTD Gene:2921 CXCL3

dbSNP Gene:2921 CXCL3

ENSEMBL:ENSG00000163734 CXCL3

HGNC:4604 CXCL3

KEGG Gene (Homo sapiens):2921 CXCL3

Monarch:2921 CXCL3

NCBI Gene:2921 CXCL3

OMIM:139111 CXCL3

UCSC:P19876 CXCL3

Reference Transcript

RefSeq:NM_002090.2 CXCL3

Other Identifiers

0006590541

11728476_a_at

11728477_at

16976833

207850_at

2731385

2773388

2773389

2773393

2773395

2773396

2773399

2773400

2773401

2773445

2921

34022_at

8100984

A_24_P183150

A_24_P251764

GE81114

GO:0002376

GO:0003674

GO:0005125

GO:0005575

GO:0005576

GO:0005615

GO:0006935

GO:0006950

GO:0006952

GO:0006954

GO:0006955

GO:0007165

GO:0007186

GO:0008009

GO:0008150

GO:0030593

GO:0030595

GO:0040011

GO:0045236

GO:0048870

GO:0061844

GO:0070098

GO:0071222

ILMN_1709350

PH_hs_0005014

TC04001284.hg

X53800_s_at

g4504156_3p_at

Participant Of

hasMember

CXCR2 ligands [extracellular region]

Inferred To

cxcl18b [extracellular region] (Danio rerio)

Homologues of CXCL1(35-107) [extracellular region] (Danio rerio)

LOC101883994 [extracellular region] (Danio rerio)

cxcl8b.1 [extracellular region] (Danio rerio)

CXCL8 [extracellular region] (Danio rerio)

Cxcl1 [extracellular region] (Mus musculus)

Cxcl1 [extracellular region] (Rattus norvegicus)

cxcl20 [extracellular region] (Danio rerio)

cxcl8b.3 [extracellular region] (Danio rerio)

cxcl8a [extracellular region] (Danio rerio)

cxcl19 [extracellular region] (Danio rerio)

LOC422654 [extracellular region] (Gallus gallus)

CXCL1(35-107) [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_002081.2

OpenTargets

ENSG00000163734

GeneCards

P19876

HPA

ENSG00000163734-CXCL3

Ensembl

ENST00000296026, ENSG00000163734, ENSP00000296026

PRO

P19876