SDK1 homophillic interaction

Stable Identifier
R-HSA-373745
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SDK1 and SDK2 are homophilic adhesion molecules. Cells expressing them exhibit a strong preference to interact exclusively with cells expressing the same sidekick form. The N-terminal four Ig domains are arranged in a horseshoe conformation and mediate homophilic adhesion, with Ig1-2 conferring the majority of binding affinity and differential specificity.

Literature References
PubMed ID Title Journal Year
17307840 The homophilic adhesion molecule sidekick-1 contributes to augmented podocyte aggregation in HIV-associated nephropathy

Kaufman, L, Yang, G, Hayashi, K, Ashby, JR, Huang, L, Ross, MJ, Klotman, ME, Klotman, PE

FASEB J 2007
12230981 Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina

Yamagata, M, Weiner, JA, Sanes, JR

Cell 2002
Participants
Participant Of
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Orthologous Events
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