Reactome | SDK1 homophillic interaction

SDK1 homophillic interaction

Stable Identifier

R-HSA-373745

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SDK1 and SDK2 are homophilic adhesion molecules. Cells expressing them exhibit a strong preference to interact exclusively with cells expressing the same sidekick form. The N-terminal four Ig domains are arranged in a horseshoe conformation and mediate homophilic adhesion, with Ig1-2 conferring the majority of binding affinity and differential specificity.

Literature References

PubMed ID	Title	Journal	Year
12230981	Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina Weiner, JA, Sanes, JR, Yamagata, M	Cell	2002
17307840	The homophilic adhesion molecule sidekick-1 contributes to augmented podocyte aggregation in HIV-associated nephropathy Ashby, JR, Kaufman, L, Klotman, ME, Klotman, PE, Huang, L, Hayashi, K, Ross, MJ, Yang, G	FASEB J	2007