SDK1 and SDK2 are homophilic adhesion molecules. Cells expressing them exhibit a strong preference to interact exclusively with cells expressing the same sidekick form. The N-terminal four Ig domains are arranged in a horseshoe conformation and mediate homophilic adhesion, with Ig1-2 conferring the majority of binding affinity and differential specificity.
Kaufman, L, Yang, G, Hayashi, K, Ashby, JR, Huang, L, Ross, MJ, Klotman, ME, Klotman, PE
Yamagata, M, Weiner, JA, Sanes, JR
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