SDK1 and SDK2 are homophilic adhesion molecules. Cells expressing them exhibit a strong preference to interact exclusively with cells expressing the same sidekick form. The N-terminal four Ig domains are arranged in a horseshoe conformation and mediate homophilic adhesion, with Ig1-2 conferring the majority of binding affinity and differential specificity.
Weiner, JA, Sanes, JR, Yamagata, M
Ashby, JR, Kaufman, L, Klotman, ME, Klotman, PE, Huang, L, Hayashi, K, Ross, MJ, Yang, G
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