SDK interactions

Stable Identifier
R-HSA-373756
Type
Pathway
Species
Homo sapiens
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Sidekick-1 (SDK1) and sidekick-2 (SDK2) are cell adhesion molecules of the immunoglobulin superfamily expressed by nonoverlapping subsets of retinal neurons. They have been shown to function as neuronal targeting molecules, guiding developing neurons to specific synapses.
SDKs are concentrated at synapses that connect SDK-expressing pre- and postsynaptic partners, suggesting that their homophilic adhesion properties promote formation or stabilization of synapses.

SDKs promotes lamina-specific synaptic connections in the retina and are specifically required for the formation of neuronal circuits that detect motion (Krishnaswamy et al. 2015).

Literature References
PubMed ID Title Journal Year
12230981 Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina

Yamagata, M, Weiner, JA, Sanes, JR

Cell 2002
20562105 Up-regulation of the homophilic adhesion molecule sidekick-1 in podocytes contributes to glomerulosclerosis

Kaufman, L, Potla, U, Coleman, S, Dikiy, S, Hata, Y, Kurihara, H, He, JC, D'Agati, VD, Klotman, PE

J. Biol. Chem. 2010
27644106 Molecular basis of sidekick-mediated cell-cell adhesion and specificity

Goodman, KM, Yamagata, M, Jin, X, Mannepalli, S, Katsamba, PS, Ahlsén, G, Sergeeva, AP, Honig, B, Sanes, JR, Shapiro, L

Elife 2016
18216854 Dscam and Sidekick proteins direct lamina-specific synaptic connections in vertebrate retina

Yamagata, M, Sanes, JR

Nature 2008
15703275 Definition of the critical domains required for homophilic targeting of mouse sidekick molecules

Hayashi, K, Kaufman, L, Ross, MD, Klotman, PE

FASEB J. 2005
20219992 Synaptic localization and function of Sidekick recognition molecules require MAGI scaffolding proteins

Yamagata, M, Sanes, JR

J. Neurosci. 2010
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