Sidekick-1 (SDK1) and sidekick-2 (SDK2) are cell adhesion molecules of the immunoglobulin superfamily expressed by nonoverlapping subsets of retinal neurons. They have been shown to function as neuronal targeting molecules, guiding developing neurons to specific synapses.SDKs are concentrated at synapses that connect SDK-expressing pre- and postsynaptic partners, suggesting that their homophilic adhesion properties promote formation or stabilization of synapses. SDKs promotes lamina-specific synaptic connections in the retina and are specifically required for the formation of neuronal circuits that detect motion (Krishnaswamy et al. 2015).
Kurihara, H, Potla, U, Kaufman, L, Hata, Y, Dikiy, S, Coleman, S, Klotman, PE, He, JC, D'Agati, VD
Weiner, JA, Sanes, JR, Yamagata, M
Honig, B, Goodman, KM, Katsamba, PS, Sanes, JR, Sergeeva, AP, Jin, X, Ahlsén, G, Mannepalli, S, Shapiro, L, Yamagata, M
Sanes, JR, Yamagata, M
Kaufman, L, Hayashi, K, Klotman, PE, Ross, MD
© 2023 Reactome
