DCC interacts with DIP13alpha

Stable Identifier
R-HSA-373717
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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DCC interacts with DIP13alpha
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The ADD domain of DCC binds DCC-interacting 13alpha (DIP13alpha), which serves as an adaptor mediating the DCC apoptotic signal. The DIP13alpha protein has a pleckstrin homology domain and a phosphotyrosine binding domain. It interacts with the ADD region on the DCC cytoplasmic domain that is available after the caspase cleavage. This interaction is required for the induction of apoptosis.
Literature References
PubMed ID Title Journal Year
12011067 Mediation of the DCC apoptotic signal by DIP13 alpha

Wu, R, Yao, F, Liu, J, Finley RL, Jr, Morgan, M, Chen, YQ, Thorburn, A

J Biol Chem 2002
11248093 The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation

Mehlen, P, Bredesen, DE, Ye, X, Shin, H, Corset, V, Granger, L, Forcet, C

Proc Natl Acad Sci U S A 2001
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Orthologous Events
DCC interacts with DIP13alpha (Bos taurus)
DCC interacts with DIP13alpha (Canis familiaris)
DCC interacts with DIP13alpha (Mus musculus)
DCC interacts with DIP13alpha (Rattus norvegicus)
DCC interacts with DIP13alpha (Sus scrofa)
Authored
Garapati, P V  (2008-07-16)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2008-07-16)
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