The ADD domain of DCC binds DCC-interacting 13alpha (DIP13alpha), which serves as an adaptor mediating the DCC apoptotic signal. The DIP13alpha protein has a pleckstrin homology domain and a phosphotyrosine binding domain. It interacts with the ADD region on the DCC cytoplasmic domain that is available after the caspase cleavage. This interaction is required for the induction of apoptosis.
Wu, R, Yao, F, Liu, J, Finley RL, Jr, Morgan, M, Chen, YQ, Thorburn, A
Mehlen, P, Bredesen, DE, Ye, X, Shin, H, Corset, V, Granger, L, Forcet, C
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