Reactome | DCC interacts with DIP13alpha

DCC interacts with DIP13alpha

Stable Identifier

R-HSA-373717

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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The ADD domain of DCC binds DCC-interacting 13alpha (DIP13alpha), which serves as an adaptor mediating the DCC apoptotic signal. The DIP13alpha protein has a pleckstrin homology domain and a phosphotyrosine binding domain. It interacts with the ADD region on the DCC cytoplasmic domain that is available after the caspase cleavage. This interaction is required for the induction of apoptosis.

Literature References

PubMed ID	Title	Journal	Year
12011067	Mediation of the DCC apoptotic signal by DIP13 alpha Liu, J, Yao, F, Wu, R, Morgan, M, Thorburn, A, Finley RL, Jr, Chen, YQ	J Biol Chem	2002
11248093	The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation Forcet, C, Ye, X, Granger, L, Corset, V, Shin, H, Bredesen, DE, Mehlen, P	Proc Natl Acad Sci U S A	2001