Caspase activation via Dependence Receptors in the absence of ligand

Stable Identifier
R-HSA-418889
Type
Pathway
Species
Homo sapiens
Synonyms
Ligand-independent caspase activation via DCC
ReviewStatus
5/5
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Caspase activation via Dependence Receptors in the absence of ligand
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In the presence of Netrin1, DCC and UNC5 generate attractive and repulsive signals to growing axons. In the absence of Netrin-1, DCC induces cell death signaling initiated via caspase cleavage of DCC and the interaction of caspase-9. Recent reports have shown that UNC5 receptors similarly induce apoptosis in the absence of Netrin-1. These reactions proceed without a requirement for cytochrome c release from mitochondria or interaction with apoptotic protease activating factor 1 (APAF1). DCC thus regulates an apoptosome-independent pathway for caspase activation. DCC and UNC-5 are hence defined as dependence receptors. Dependence receptors exhibit dual functions depending on the availability of ligand. They create cellular states of dependence on their respective ligands by either inducing apoptosis when unoccupied by the ligand, or inhibiting apoptosis in the presence of the ligand.
Literature References
PubMed ID Title Journal Year
12011067 Mediation of the DCC apoptotic signal by DIP13 alpha

Liu, J, Yao, F, Wu, R, Morgan, M, Thorburn, A, Finley RL, Jr, Chen, YQ

J Biol Chem 2002
12598906 p53RDL1 regulates p53-dependent apoptosis

Tanikawa, C, Matsuda, K, Fukuda, S, Nakamura, Y, Arakawa, H

Nat Cell Biol 2003
15310786 Role of the dependence receptor DCC in colorectal cancer pathogenesis

Mehlen, P, Fearon, ER

J Clin Oncol 2004
10348349 Induction of apoptosis and G2/M cell cycle arrest by DCC

Chen, YQ, Hsieh, JT, Yao, F, Fang, B, Pong, RC, Cipriano, SC, Krepulat, F

Oncogene 1999
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Event Information
Go Biological Process
extrinsic apoptotic signaling pathway in absence of ligand (0097192)
Orthologous Events
Caspase activation via Dependence Receptors in the absence of ligand (Bos taurus)
Caspase activation via Dependence Receptors in the absence of ligand (Canis familiaris)
Caspase activation via Dependence Receptors in the absence of ligand (Danio rerio)
Caspase activation via Dependence Receptors in the absence of ligand (Drosophila melanogaster)
Caspase activation via Dependence Receptors in the absence of ligand (Mus musculus)
Caspase activation via Dependence Receptors in the absence of ligand (Rattus norvegicus)
Caspase activation via Dependence Receptors in the absence of ligand (Sus scrofa)
Caspase activation via Dependence Receptors in the absence of ligand (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Garapati, P V  (2008-07-16)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2009-04-27)
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