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CCL19 [extracellular region]
Stable Identifier
R-HSA-373094
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
C-C motif chemokine 19, CCL19_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-10 signaling (Homo sapiens)
IL10 negatively regulates extracellular inflammatory mediators (Homo sapiens)
IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)
CCL19 [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR7:CCL19,21 [plasma membrane] (Homo sapiens)
CCL19,21 [extracellular region] (Homo sapiens)
CCL19 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR7:CCL19,21 [plasma membrane] (Homo sapiens)
CCL19,21 [extracellular region] (Homo sapiens)
CCL19 [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR7:CCL19,21 [plasma membrane] (Homo sapiens)
CCL19,21 [extracellular region] (Homo sapiens)
CCL19 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR7:CCL19,21 [plasma membrane] (Homo sapiens)
CCL19,21 [extracellular region] (Homo sapiens)
CCL19 [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR7:CCL19,21 [plasma membrane] (Homo sapiens)
CCL19,21 [extracellular region] (Homo sapiens)
CCL19 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR7:CCL19,21 [plasma membrane] (Homo sapiens)
CCL19,21 [extracellular region] (Homo sapiens)
CCL19 [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Chemokine receptors bind chemokines (Homo sapiens)
CCRL2 binds CCL19 (Homo sapiens)
CCL19 [extracellular region] (Homo sapiens)
CCRL2:CCL19 [plasma membrane] (Homo sapiens)
CCL19 [extracellular region] (Homo sapiens)
Receptor CCR11 binds CCL19, CCL21 & CCL25 (Homo sapiens)
CCL19, CCL21, CCL25 [extracellular region] (Homo sapiens)
CCL19 [extracellular region] (Homo sapiens)
CCR11:CCL19,21,25 [plasma membrane] (Homo sapiens)
CCL19, CCL21, CCL25 [extracellular region] (Homo sapiens)
CCL19 [extracellular region] (Homo sapiens)
Receptor CCR7 binds CCL19 and 21 ligands (Homo sapiens)
CCL19,21 [extracellular region] (Homo sapiens)
CCL19 [extracellular region] (Homo sapiens)
CCR7:CCL19,21 [plasma membrane] (Homo sapiens)
CCL19,21 [extracellular region] (Homo sapiens)
CCL19 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99731 CCL19
Gene Names
CCL19, ELC, MIP3B, SCYA19
Chain
signal peptide:1-21, chain:22-98
Reference Genes
BioGPS Gene:6363 CCL19
COSMIC (genes):CCL19 CCL19
CTD Gene:6363 CCL19
dbSNP Gene:6363 CCL19
ENSEMBL:ENSG00000172724 CCL19
HGNC:10617 CCL19
KEGG:hsa:6363 CCL19
Monarch:6363 CCL19
NCBI Gene:6363 CCL19
OMIM:602227 CCL19
UCSC:Q99731 CCL19
Reference Transcript
RefSeq:NM_006274.2 CCL19
Other Identifiers
11721685_at
17093536
210072_PM_at
210072_at
3204287
3204288
3204289
3204290
3204291
3204292
3204293
3204294
36067_at
6363
8160879
A_23_P123853
A_33_P3377151
GE53023
GO:0001768
GO:0001771
GO:0002376
GO:0002407
GO:0002408
GO:0002606
GO:0005125
GO:0005515
GO:0005576
GO:0005615
GO:0006874
GO:0006935
GO:0006954
GO:0006955
GO:0007154
GO:0007163
GO:0007165
GO:0008009
GO:0009615
GO:0010560
GO:0016477
GO:0030154
GO:0030335
GO:0031295
GO:0031732
GO:0031735
GO:0032731
GO:0032735
GO:0032760
GO:0034695
GO:0042102
GO:0042379
GO:0043123
GO:0043507
GO:0043547
GO:0045627
GO:0045807
GO:0045860
GO:0046330
GO:0048018
GO:0048020
GO:0048260
GO:0048469
GO:0048870
GO:0050921
GO:0051209
GO:0051897
GO:0055085
GO:0060326
GO:0060491
GO:0061844
GO:0070098
GO:0070374
GO:0071731
GO:0090023
GO:0097029
GO:0098542
GO:0098586
GO:0098772
GO:1901224
GO:2000147
GO:2000549
GO:2000669
HMNXSV003000075
ILMN_1769129
PH_hs_0003467
TC09001044.hg
U77180_at
g2196921_3p_at
Participates
as a member of
IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)
CCL19, CCL21, CCL25 [extracellular region] (Homo sapiens)
CCL19,21 [extracellular region] (Homo sapiens)
as a component of
CCRL2:CCL19 [plasma membrane] (Homo sapiens)
as an input of
CCRL2 binds CCL19 (Homo sapiens)
Inferred To
ccl19a.1 [extracellular region]
(Danio rerio)
Ccl19 [extracellular region]
(Mus musculus)
Ccl19 [extracellular region]
(Rattus norvegicus)
CCL19 [extracellular region]
(Bos taurus)
CCL19 [extracellular region]
(Canis familiaris)
CCL19 [extracellular region]
(Gallus gallus)
CCL19 [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_006265.1
ENSEMBL
ENSP00000308815
,
ENST00000311925
,
ENSG00000172724
OpenTargets
ENSG00000172724
GeneCards
CCL19
HPA
ENSG00000172724-CCL19
PRO
Q99731
Pharos - Targets
Q99731
PDB
7STA
,
2MP1
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6FHY5 Q6FHY5
0.556
3
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