CCRL2 binds CCL19

Stable Identifier
R-HSA-3296301
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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CCRL2 binds CCL19
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CCRL2 binds the chemokine CCL19 with an affinity similar to the binding of CCL19 to its other receptor CCR7. In contrast to the known CCL19:CCR7 ligand:receptor interaction, binding to CCRL2 does not result in cellular activation. Instead CCRL2 is constitutively recycled via clathrin-coated pits. Thus CCRL2 may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19.
Literature References
PubMed ID Title Journal Year
20002784 CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B

Leick, M, Veelken, H, Follo, M, Hartmann, TN, Burger, M, Nibbs, RJ, Catusse, J

Immunology 2010
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Orthologous Events
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Authored
Jupe, S  (2013-04-18)
Reviewed
D'Eustachio, P  (2013-05-16)
Created
Jupe, S  (2013-04-18)
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