Receptor CCR9 binds CCL25 ligand

Stable Identifier
R-HSA-373074
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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CCR9 (previously called orphan receptor GPR 9-6) is highly expressed in the thymus on both mature and immature T-cells. It is also abundant in T-cells of the intestine but is lowly expressed in lymph nodes and the spleen. Alternative splicing produces two receptors, called CCR9A and CCR9B, CCR9A containing 12 additional amino acids at its N terminus as compared with CCR9B (Yu CR et al, 2000). The A and B forms of the receptor were expressed at a ratio of approximately 10:1. CCR9 has a specific ligand in CCL25 (Thymus-expressed chemokine, TECK) (Zaballos A et al, 1999) and transduces the signal by intracellular calcium mobilization.

Literature References
PubMed ID Title Journal Year
10640743 CCR9A and CCR9B: two receptors for the chemokine CCL25/TECK/Ck beta-15 that differ in their sensitivities to ligand

Yu, CR, Peden, KW, Zaitseva, MB, Golding, H, Farber, JM

J Immunol 2000
10229797 Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK

Zaballos, A, Gutiérrez, J, Varona, R, Ardavin, C, Márquez, G

J Immunol 1999
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