Reactome | SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine

SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine

Stable Identifier

R-HSA-352371

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine

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SLC1A4, associated with the plasma membrane, mediates the exchange of threonine and an extracellular sodium ion for a cytosolic sodium ion and any one of the four amino acids alanine, serine, threonine, or cysteine (Zerangue and Kavanaugh 1996).

Literature References

PubMed ID	Title	Journal	Year
8101838	Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family Wu, YN, Murdoch, GH, Arriza, JL, Amara, SG, North, RA, Kavanaugh, MP, Fairman, WA	J Biol Chem	1993
8910405	ASCT-1 is a neutral amino acid exchanger with chloride channel activity Zerangue, N, Kavanaugh, MP	J Biol Chem	1996
8340364	Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters Shafqat, S, Kilberg, MS, Puranam, RS, Tamarappoo, BK, McNamara, JO, Fremeau RT, Jr, Guadaño-Ferraz, A	J Biol Chem	1993