SLC16A10-mediated uptake of aromatic amino acids

Stable Identifier
R-HSA-352158
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SLC16A10 mediates the reversible facilitated diffusion of phenylalanine, tyrosine, and tryptophan across the plasma membrane. The process is Na+-independent and not coupled to H+ transport. As measured by Northern blotting SLC16A10 is widely expressed in the body but especially abundant in kidney. In situ hybridization studies indicate that the gene product is abundant in kidney proximal tubules (Kim et al. 2001; Kim et al. 2002; Park et al. 2005).

Literature References
PubMed ID Title Journal Year
15918515 Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule

Park, SY, Kim, JK, Kim, IJ, Choi, BK, Jung, KY, Lee, S, Park, KJ, Chairoungdua, A, Kanai, Y, Endou, H, Kim, DK

Arch Pharm Res 2005
11827462 The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location

Kim, DK, Kanai, Y, Matsuo, H, Kim, JY, Chairoungdua, A, Kobayashi, Y, Enomoto, A, Cha, SH, Goya, T, Endou, H

Genomics 2002
11278508 Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters

Kim, DK, Kanai, Y, Chairoungdua, A, Matsuo, H, Cha, SH, Endou, H

J Biol Chem 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
amino acid transmembrane transporter activity of SLC16A10 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
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