Reactome | SLC43A1 (LAT3)-mediated uptake of large neutral amino acids

SLC43A1 (LAT3)-mediated uptake of large neutral amino acids

Stable Identifier

R-HSA-352103

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SLC43A1 (LAT3)-mediated uptake of large neutral amino acids

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SLC43A1 (LAT3), associated with the plasma membrane, mediates the uptake of isoleucine, leucine, methionine, phenylalanine, and valine in a biphasic and sodium ion-independent transport process. Northern blotting experiments indicate gene expression in liver, pancreas, and skeletal muscle, and at lower levels in many tissues including kidney and intestine (Babu et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12930836	Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters Babu, E, Kanai, Y, Chairoungdua, A, Kim, DK, Iribe, Y, Tangtrongsup, S, Jutabha, P, Li, Y, Ahmed, N, Sakamoto, S, Anzai, N, Nagamori, S, Endou, H	J Biol Chem	2003