SLC43A1 (LAT3)-mediated uptake of large neutral amino acids

Stable Identifier
R-HSA-352103
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SLC43A1 (LAT3), associated with the plasma membrane, mediates the uptake of isoleucine, leucine, methionine, phenylalanine, and valine in a biphasic and sodium ion-independent transport process. Northern blotting experiments indicate gene expression in liver, pancreas, and skeletal muscle, and at lower levels in many tissues including kidney and intestine (Babu et al. 2003).

Literature References
PubMed ID Title Journal Year
12930836 Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters

Babu, E, Kanai, Y, Chairoungdua, A, Kim, DK, Iribe, Y, Tangtrongsup, S, Jutabha, P, Li, Y, Ahmed, N, Sakamoto, S, Anzai, N, Nagamori, S, Endou, H

J Biol Chem 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
amino acid transmembrane transporter activity of SLC43A1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
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