Reactome | Caspase-mediated cleavage of MST3

Caspase-mediated cleavage of MST3

Stable Identifier

R-HSA-351901

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Caspase-mediated cleavage of Mst3 activates its intrinsic kinase activity. Proteolytic removal of the COOH-terminal domain promotes nuclear translocation of its kinase domain. Ectopic expression of COOH-terminal truncated Mst3 results in DNA fragmentation and morphological changes characteristic of apoptosis (Huang et al., 2002). Both CASP3 and CASP7 can cleave MST3, and phosphorylation of MST3 may promote facilitate caspase-mediated cleavage (Turowec et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
12107159	Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis Huang, CY, Hsu, CY, Fang, HI, Robinson, DR, Wu, YM, Huang, CL, Lai, MD, Yuan, CJ, Kung, HJ, Leu, TH, Shih, HM, Lee, WS, Lu, TJ	J Biol Chem	2002
24556848	An unbiased proteomic screen reveals caspase cleavage is positively and negatively regulated by substrate phosphorylation Graves, LM, Johnson, GL, Knight, JD, Lajoie, GA, Litchfield, DW, Li, SS, Turowec, JP, Smalley, DM, Zukowski, SA	Mol. Cell Proteomics	2014