Caspase mediated cleavage of BAP31

Stable Identifier
R-HSA-351894
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Caspase-8 mediated cleavage of BAP31 at the ER produces a pro-apoptotic p20 fragment that remains at the ER (Breckenridgeet al., 2003). Cleavage stimulates Ca2+-dependent mitochondrial fission, enhancing the release of cytochrome C (Breckenridgeet al., 2003).

Literature References
PubMed ID Title Journal Year
12668660 Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol

Breckenridge, DG, Stojanovic, M, Marcellus, RC, Shore, GC

J Cell Biol 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of active caspase-8 [mitochondrial outer membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created