Caspase mediated cleavage of BAP31

Stable Identifier
R-HSA-351894
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
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Caspase mediated cleavage of BAP31
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Caspase-8 mediated cleavage of BAP31 at the ER produces a pro-apoptotic p20 fragment that remains at the ER (Breckenridgeet al., 2003). Cleavage stimulates Ca2+-dependent mitochondrial fission, enhancing the release of cytochrome C (Breckenridgeet al., 2003).

Literature References
PubMed ID Title Journal Year
12668660 Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol

Breckenridge, DG, Stojanovic, M, Marcellus, RC, Shore, GC

J Cell Biol 2003
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Output
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as an event of
Catalyst Activity

cysteine-type endopeptidase activity of active caspase-8 [mitochondrial outer membrane]

Physical Entity
active caspase-8 [mitochondrial outer membrane] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
Caspase mediated cleavage of BAP31 (Bos taurus)
Caspase mediated cleavage of BAP31 (Canis familiaris)
Caspase mediated cleavage of BAP31 (Danio rerio)
Caspase mediated cleavage of BAP31 (Gallus gallus)
Caspase mediated cleavage of BAP31 (Mus musculus)
Caspase mediated cleavage of BAP31 (Rattus norvegicus)
Caspase mediated cleavage of BAP31 (Sus scrofa)
Authored
Schulze-Osthoff, K  (2008-05-18)
Reviewed
Ranganathan, S  (2008-06-11)
Created
Matthews, L  (2008-05-29)
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