Caspase-8 mediated cleavage of BAP31 at the ER produces a pro-apoptotic p20 fragment that remains at the ER (Breckenridgeet al., 2003). Cleavage stimulates Ca2+-dependent mitochondrial fission, enhancing the release of cytochrome C (Breckenridgeet al., 2003).
Stojanovic, M, Marcellus, RC, Shore, GC, Breckenridge, DG
cysteine-type endopeptidase activity of active caspase-8 [mitochondrial outer membrane]
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